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ScienceDirect
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Combination of Nivolumab Immunotherapy with Radiation …
2024年10月1日 · Survival outcomes of grade group 5 (GG5) prostate cancer (PCa) after standard of care therapy (SOC) remain poor. Evidence suggests that high-dose rate brachytherapy …
ScienceDirect
https://www.sciencedirect.com › science › article › pii
PD-L1 expression in prostate cancer and Gleason Grade
1 天前 · Notably, GG5, representing the most aggressive form of PCa, exhibited the highest prevalence of PD-L1 expression. This finding carries substantial clinical implications, …
PubMed
https://pubmed.ncbi.nlm.nih.gov
Cribriform morphology is associated with higher risk of …
Aims: Grade Group 5 (GG5) prostate cancer (PCa) is associated with a high risk of disease recurrence after radical prostatectomy (~75% at 5 years). However, this is a heterogeneous …
GG5 Pca 的研究
PubMed
Cribriform morphology is associated with higher risk of biochemical recurrence after radical prostatectomy in patients with Grade Group 5 prostate cancer
Aims: Grade Group 5 (GG5) prostate cancer (PCa) is associated with a high risk of disease recurrence after radical prostatectomy (~75% at 5 years). However, this is a heterogeneous category that includes neoplasms with different combinations of Gleason pattern (GP) 4 and 5. Within GP4, large cribrif...
作者: Jihane Oufattole
已发布: 2023/6
Keywords: Grade Gro…
PubMed
The Significance of Primary Biopsy Gleason 5 in Patients with Grade Group 5 Prostate Cancer
The five-tier grade group (GG) classification for prostate cancer (PCa) does not differentiate between primary (5+4) or secondary (4+5) histological Gleason 5 pattern in GG 5. We addressed the prognostic value of primary versus secondary biopsy Gleason 5 for GG 5 among 18 555 PCa patients treated wi...
作者: Derya Tilki
已发布: 2020/03/15
Keywords: Gleason gr…
ScienceDirect
Temporal Trends and Predictors in Diagnosing Pathologic Node-Positive Prostate Cancer in Clinically Node-Negative Patients
Introduction Managing pathologically node positive (pN+) prostate cancer (PCa) is controversial. We describe temporal patterns and predictors of pN+ PCa in men with initially surgically managed clinically node negative (cN–) PCa. Materials and Methods This observational retrospective analysis...
已发布: 2021/12/01
Cited By: 0
DOI: 10.1016/j.clgc.202…
PubMed
Temporal Trends and Predictors in Diagnosing Pathologic Node-Positive Prostate Cancer in Clinically Node-Negative Patients
Introduction: Managing pathologically node positive (pN+) prostate cancer (PCa) is controversial. We describe temporal patterns and predictors of pN+ PCa in men with initially surgically managed clinically node negative (cN-) PCa. Materials and methods: This observational retrospective analysis ...
作者: Ryan J Hutten
已发布: 2021/12
Keywords: Managing …
National Center for Biotechnology Information
Grade group system and plasma androgen receptor status in the first line treatment for metastatic castration resistant prostate cancer
Since 1996, the Gleason score system (GS) provides a risk stratification in men with localized prostate cancer (PCa) basing on histologic architectural patterns1. In localised PCa, GS system predicts biochemical relapse, metastatic disease-free survival and overall survival (OS)2. In 2005 and more r...
作者: M. C. Cursano, V…
已发布: 2022
Publication: Sci Rep. …
National Center for Biotechnology Information
Proof-of-principle Phase I results of combining nivolumab with brachytherapy and external beam radiation therapy for Grade Group 5 prostate cancer: safety, feasibility, and exploratory analysis
Immunotherapy with checkpoint inhibitors has revolutionized the treatment paradigm of many malignancies over the past five years [1–4]. However, immune checkpoint inhibitors (ICIs) have not demonstrated comparable rates of efficacy in prostate cancer (PCa) [5]. Early evidence demonstrated that there...
作者: Zhigang Yuan, D…
已发布: 2021/03
DOI: 10.1038/s41391-0…
ScienceDirect
Association of Brachytherapy Boost with Overall Survival for Gleason 9-10 Prostate Cancer: The Impact of Primary versus Secondary Pattern 5
PURPOSE The addition of a brachytherapy (BT) boost to external beam radiotherapy (EBRT) reduces recurrence risk in men with high-risk prostate cancer (PCa) and may reduce PCa-mortality for Gleason grade group 5 (GG5). Whether the extent of pattern five, a risk factor for distant metastases, impacts...
已发布: 2023/05/01
Cited By: 0
Keywords: Brachyther…
PubMed
Rare Germline Pathogenic Mutations of DNA Repair Genes Are Most Strongly Associated with Grade Group 5 Prostate Cancer
Background: Rare germline mutations in several genes, primarily DNA repair genes, have been proposed to predict worse prognosis of prostate cancer (PCa). Objective: To compare the frequency of germline pathogenic mutations in commonly assayed PCa genes between high- and low-grade PCa in patients...
作者: Yishuo Wu
已发布: 2020/4
Keywords: Rare germli…
Nature
https://www.nature.com › articles
Proof-of-principle Phase I results of combining …
2020年7月10日 · This Phase I/II trial targeting GG5 PCa with a novel combination regimen may provide more insights into patient selection and development of …
作者: Zhigang Yuan, Daniel Fernandez, Jasreman Dhillon, Julieta Abraham-Miranda, Shivanshu Awasthi, Youngc...
Publish Year: 2021
PubMed
https://pubmed.ncbi.nlm.nih.gov
The Significance of Primary Biopsy Gleason 5 in Patients with …
2020年3月15日 · The five-tier grade group (GG) classification for prostate cancer (PCa) does not differentiate between primary (5+4) or secondary (4+5) histological Gleason 5 pattern in GG 5. …
- 作者: Derya Tilki, Christoph Würnschimmel, Felix Preisser, Markus Graefen, Hartwig Huland, Philipp Mandel,...
- Publish Year: 2020
American Association for Cancer Research
https://aacrjournals.org › cancerres › article
Abstract - American Association for Cancer Research
2023年4月14日 · Here we report an interim analysis of a single-center single-arm phase II trial exploring this novel combination therapy with nivolumab for GG5 PCa. Patients were enrolled …
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What is the difference between GG 2 & GG 5 mCRPC?
Patients with GG5 presented greater tumor burden (in terms of visceral, lymph nodes and bone metastases) compared to those patients with GG 2–4 (Table 1 ). Patients with GG 5 presented shorter time from initial diagnosis to the beginning of treatment for mCRPC than patients with GG 2–4.
Grade group system and plasma androgen receptor status in the ... - Na…
nature.com
How do GS and GG PREDICT Prostate cancer recurrence?
The GS system and the latest GG system provide a risk assessment in men with localized prostate cancer by predicting biochemical recurrence, development of metastasis and overall survival 2, 3. In localized hormone-sensitive PCa, the presence of GG 4 and GG 5 identifies worse prognosis patients.
Grade group system and plasma androgen receptor status in the ... - Na…
nature.com
What causes TP53 alterations in gg5 prostate cancer?
In particular, TP53 alterations are frequent in GG5 prostate tumors and are associated to rapid progression and evolution towards the castration resistance phase 22. Hormone-resistance mechanisms include all AR gene aberrations: amplifications, mutations, splicing variants or changes in co-regulatory genes 19.
Grade group system and plasma androgen receptor status in the ... - Na…
nature.com
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ScienceDirect
https://www.sciencedirect.com › science › article › pii
Temporal Trends and Predictors in Diagnosing Pathologic Node …
2021年12月1日 · The most significant predictor of pN+ PCa was ISUP GG4 (odds ratio [OR] 12.5, P< .001) and GG 5 (OR 26.2, P < .001). Rates of pN+ identification increased from 5.5% to …
PubMed
https://pubmed.ncbi.nlm.nih.gov
Temporal Trends and Predictors in Diagnosing Pathologic Node
The most significant predictor of pN+ PCa was ISUP GG4 (odds ratio [OR] 12.5, P< .001) and GG 5 (OR 26.2, P < .001). Rates of pN+ identification increased from 5.5% to 9.4% in men with …
Nature
https://www.nature.com › articles
Grade group system and plasma androgen receptor status in the …
2022年5月5日 · Recent studies demonstrated that GS 9–10/GG 5 hormone sensitive PCa may benefit less from androgen deprivation therapy (ADT) and should be treated with lifelong ADT, …
Springer
https://link.springer.com › article
The prognostic significance of the clinical T stage and Grade …
2023年5月25日 · The clinical T stage and GG status were significantly prognostic of oncological outcomes in patients with locally advanced PCa. In patients of GG ≤ 4 PCa, HDR-BT was …
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