Gamma-hydroxybutyrate / butyric acid, ambiguously called GHB, presents some unique challenges for analysis due in part to its acidity, high polarity, and high solubility in aqueous solution.

2001年10月15日 · A sensitive and specific gas chromatography–mass spectrometer (GC–MS) method using selective ion monitoring (SIM) has been developed for the quantification of gamma-hydroxybutyric acid (GHB) in blood.

2007年8月6日 · Here we describe an assay for GHB, GBL and BD in blood and/or urine samples. GHB and BD were extracted from diluted 200 μL aliquots of samples with t -butylmethylether (plus internal standard benzyl alcohol) in test tubes preloaded with NaCl.

Gamma-Hydroxy-butyrate (GHB) is an endogenous metabolite found in most mammalian tissues at nanomolar concentra-tions. The sodium salt has been promoted as a steroid alternative as well as a tryptophan replacement. GHB often involves oral doses of the salt dissolved in water.

Gamma-hydroxybutyric acid (GHB), a minor metabolite or precursor of gamma-aminobutyric acid (GABA), acts as a neurotransmitter/neuromodulator via binding to GABA...

2014年2月6日 · First, possible screening procedures for GHB are discussed, including colorimetric, enzymatic, and chromatography-based procedures. Confirmation methods for clinical and forensic cases mostly involve gas chromatography (coupled to mass spectrometry), although liquid chromatography and capillary zone electrophoresis have also been used.

A simple liquid-liquid extraction procedure for the analysis of gamma-hydroxybutyrate (GHB) in biological fluids without conversion to its lactone, gamma-butyrolactone, is described. Following derivatization to its di-TMS derivative, GHB was detected using gas chromatography-electron impact mass spe …

This paper discusses the chemistry of gamma-hydroxybutyric acid (GHB), particularly its equilibrium with gamma-butyrolactone (GBL) in aqueous solutions. It delves into the species present at different pH levels, their stability, and implications for chemical identification in various samples, including drinks.

2011年1月1日 · A simple liquid chromatography-tandem mass spectrometry (LC-MS-MS) method has been developed and validated for simultaneous identification and quantification of γ-hydroxybutyrate (GHB), γ-butyrolactone (GBL), 1.4-butanediol (1.4-BD), and γ-valerolactone (GVL) in whole blood from forensic cases.

2022年12月23日 · Gamma-hydroxybutyric acid (GHB) represents an important drug in clinical and forensic toxicology, particularly in the context of drug-facilitated crimes. Analytically, GHB remains a major challenge given its endogenous occurrence and short detection window.