2005年8月21日 · Growth hormone is believed to activate the growth hormone receptor (GHR) by dimerizing two identical receptor subunits, leading to activation of JAK2 kinase associated with the...

2016年10月12日 · GH receptor (GHR) antagonist therapy is more effective but requires frequent high-dose injections. We have developed an alternative technology for generating a long acting potent GHR...

2024年11月13日 · Growth hormone-releasing hormone (GHRH) is a hypothalamic hypophysiotropic peptide that was discovered as a result of its ability to stimulate the synthesis and secretion of...

2023年9月15日 · 生长激素受体（growth hormone receptor, GHR）跨膜蛋白质，广泛存在于人体内各种细胞中。 它主要负责介导生长激素（GH）在目标细胞上的生物学效应，调节细胞生长、增殖和分化等生理过程。 GHR 可以通过配体结合和自身酪氨酸激酶活性的激活，促进细胞内的多种信号通路的启动，包括 JAK-STAT 、PI3K/Akt 和 Ras/MAPK 等信号通路，这些信号通路的激活将刺激多种信号转导与反应，并影响基因表达和细胞代谢。 当生长激素（GH）进入细胞后，会 …

The GHR signaling pathway plays important roles in growth, metabolism, cell cycle control, immunity, homeostatic processes, and chemoresistance via both the JAK/STAT and the SRC pathways. Dysregulation of GHR signaling is associated with various ...

2020年12月1日 · In this review, I summarize historical and recent features of the classical pathways activated by growth hormone (GH) through the cell surface GH receptor (GHR). GHR is a cytokine receptor superfamily member that signals by activating the non-receptor tyrosine kinase, JAK2, and members of the Src family kinases.

Growth Hormone (GH) and Insulin-Like Growth Factor-1 (IGF-1) are two important anabolic hormones that regulate metabolic processes including protein synthesis in almost all tissues throughout the lifespan of mammals.

GHR (буквенная аббревиатура от фамилий Gennaro, Halevi и Rabin) — схема цифровой подписи с открытым ключом.

Human GH binds to its receptor (GHR) on target cells and activates multiple intracellular pathways, leading to changes in gene expression, differentiation, and metabolism. GHR deficiency is associated with growth and metabolic disorders whereas increased GHR expression has been reported in certain c …

We found that following GH treatment, the GHR rapidly translocates to the nucleus, with maximal localisation at 5–10 min. Combined immunoprecipitation-mass spectrometry analysis of RL95-2 whole cell lysates identified 40 novel GHR binding partners, including the …