2005年8月21日 · Growth hormone is believed to activate the growth hormone receptor (GHR) by dimerizing two identical receptor subunits, leading to activation of JAK2 kinase associated with the cytoplasmic...

The growth hormone receptor (GHR) is a critical regulator of postnatal growth and metabolism. However, the GHR signaling domains and pathways that regulate these processes in vivo are not defined. We report the first knock-in mouse models with deletions of specific domains of the receptor that are required for its in vivo actions.

2020年12月1日 · In this review, I summarize historical and recent features of the classical pathways activated by growth hormone (GH) through the cell surface GH receptor (GHR). GHR is a cytokine receptor superfamily member that signals by activating the non-receptor tyrosine kinase, JAK2, and members of the Src family kinases.

Growth hormone activates the Janus kinase (JAK)–signal transducer and activator of transcription (STAT) signaling pathway, and recent studies have provided a new understanding of the mechanism of JAK2 activation by growth hormone binding to its receptor.

2016年10月12日 · GH receptor (GHR) antagonist therapy is more effective but requires frequent high-dose injections. We have developed an alternative technology for generating a long acting potent...

2021年1月15日 · Growth hormone (GH) actions via initiating cell signalling through the GH receptor (GHR) are important for many physiological processes, in addition to its well-known role in regulating growth. The activation of JAK-STAT signalling by GH is well characterized, however knowledge on GH activation of SRC family kinases (SFKs) is still limited.

2020年10月15日 · Growth hormone-releasing hormone (GHRH) regulates the secretion of growth hormone that virtually controls metabolism and growth of every tissue through its...

2023年9月15日 · 生长激素受体（growth hormone receptor, GHR）跨膜蛋白质，广泛存在于人体内各种细胞中。 它主要负责介导生长激素（GH）在目标细胞上的生物学效应，调节细胞生长、增殖和分化等生理过程。 GHR 可以通过配体结合和自身酪氨酸激酶活性的激活，促进细胞内的多种信号通路的启动，包括 JAK-STAT 、PI3K/Akt 和 Ras/MAPK 等信号通路，这些信号通路的激活将刺激多种信号转导与反应，并影响基因表达和细胞代谢。 当生长激素（GH）进入细胞后，会 …

该基因的突变与拉伦综合征有关，也称为生长激素不敏感综合征 (GHIS) ，这是一种以身材矮小为特征的疾病。 在人类和兔子而非啮齿动物中，生长激素结合蛋白 (GHBP) 是由成熟生长激素受体蛋白的胞外配体结合域的蛋白水解裂解产生的。 已发现该基因的多个可变剪接转录本变体。 [RefSeq 提供，2011 年 6 月] This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone.

Dysregulation of GHR signaling is associated with various diseases and chronic conditions such as acromegaly, cancer, aging, metabolic disease, fibroses, inflammation and autoimmunity. Numerous studies entailing the GHR signaling pathway have been conducted for various cancers.