Gap junction alpha-1 protein (GJA1), also known as connexin 43 (Cx43), is a protein that in humans is encoded by the GJA1 gene on chromosome 6. [5] [6] [7] As a connexin, GJA1 is a component of gap junctions, which allow for gap junction intercellular communication (GJIC) between cells to regulate cell death, proliferation, and differentiation. [8]

2024年12月25日 · GJA1 (Gap Junction Protein Alpha 1) is a Protein Coding gene. Diseases associated with GJA1 include Oculodentodigital Dysplasia and Syndactyly, Type Iii . Among its related pathways are Gap junction trafficking and Infectious disease .

2018年12月21日 · GJA1 (connexin43) has been predicted as the top key driver of an astrocyte enriched subnetwork associated with Alzheimer's disease (AD). In this study, we comprehensively examined GJA1 expression across 29 transcriptomic and proteomic datasets from post-mortem AD and normal control brains.

The GJA1 gene provides instructions for making a protein called gap junction alpha-1 protein. Because this protein is one of a large family of connexin proteins, it is commonly called connexin 43.

Results identified GJA1 as the downstream target of the alternatively spliced estrogen receptor alpha (ERalpha) variant ERDelta7 action in myometrium. This study demonstrated that GJA1 (connexin43) is a key regulator of Alzheimer's disease pathogenesis.

2023年2月18日 · Cx43, also known as GJA1, is the most ubiquitously expressed connexin protein. It is detected in most cell types and involved in many biological processes.

2025年2月9日 · HIV-1 Tat upregulates the expression of GJA1 (Cx43) by binding the promoter of Cx43 in human astrocytes: PubMed

缝隙连接蛋白α1： 该基因是连接蛋白基因家族的成员。编码的蛋白质是间隙连接的一个组成部分，间隙连接由细胞间通道阵列组成，这些通道为低分子量材料从细胞到细胞的扩散提供了途径。编码的蛋白质是心脏间隙连接的主要蛋白质，被认为在心脏同步收缩和胚胎发育中起着至关重要的作 …

The GJA1 gene encodes connexin-43 (Cx43), one of the most abundant connexin proteins. Cxs are a family of transmembrane proteins with molecular masses varying from 26 to 60 kD; Cx43 has a molecular mass of 43 kD.

2025年1月24日 · GJA1-20k induces focal constriction of mitochondria by actin polymerization, leading to protective mitochondrial fission. Human cervix: HeLa cell line: GJA1-20k presents a microtubule-binding domain, mediates mitochondrial transport and maintains mitochondrial network integrity during cellular stress. Human skin: HaCaT cell line : Human kidney