Targeting glutamine metabolism as a therapeutic strategy for cancer
2023年4月3日 · During anaplerosis, mitochondrial glutamate dehydrogenase 1 (GLUD1) plays a key role by catalyzing the conversion of glutamate to alpha-ketoglutarate (α-KG) and...
谷氨酸代谢 | Cell Signaling Technology
谷氨酰胺通过氨基酸转运蛋白 ASCT2/SLC1A5 进入细胞，并在线粒体中通过被谷氨酰胺酶 (GLS) 催化的脱氨反应转化为谷氨酸。 谷氨酸被谷氨酸脱氢酶 (GDH) 或丙氨酸或天冬氨酸转氨酶 …
聊聊谷氨酰胺代谢与癌症的关系——Hallmark - 知乎
针对谷氨酰胺分解最直接的方法是抑制谷氨酰胺酶 (gls)，从而抑制其催化谷氨酰胺水解为谷氨酸。 BPTES 、 CB-839 和化合物968等小分子抑制剂阻断GLS活性。
IGF2BP3-mediated regulation of GLS and GLUD1 gene expression …
2023年11月15日 · IGF2BP3 exhibits high expression in human cervical cancer and plays a crucial role in stabilizing the mRNA of GLS and GLUD1 genes, key metabolic enzymes in glutamate …
Filamentous GLS1 promotes ROS-induced apoptosis upon …
GLS1 orchestrates glutaminolysis and promotes cell proliferation when glutamine is abundant by regenerating TCA cycle intermediates and supporting redox homeostasis. CB-839, an inhibitor …
Deacetylation of GLUD1 maintains the survival of lung …
2024年10月1日 · Here, we discovered that deacetylation of glutamate dehydrogenase 1 (GLUD1), one of the key enzymes in glutamine catabolism, maintains the survival of lung …
IGF2BP3-mediated regulation of GLS and GLUD1 gene expression …
IGF2BP3 exhibits high expression in human cervical cancer and plays a crucial role in stabilizing the mRNA of GLS and GLUD1 genes, key metabolic enzymes in glutamate and glutamine …
Targeting glutaminase 1 (GLS1) by small molecules for anticancer ...
2023年4月5日 · In this manuscript, we aim to summarize the regulatory role of GLS1 in physiological and pathophysiological processes. We also provide a comprehensive overview …
Glutaminase GLS1 senses glutamine availability in a non
2018年6月22日 · In this study, we observed that mouse embryonic fibroblasts (MEFs) showed a significant increase of long tubular mitochondria or fused mitochondria within 2 h of culture in …
STUB1-mediated ubiquitination regulates the stability of GLUD1 …
2023年7月21日 · Glutamate dehydrogenase 1 (GLUD1) is one of the key enzymes in glutamine catabolism. Here, we found that enhanced protein stability was the key factor for the …