GLUD1 (glutamate dehydrogenase 1) is a mitochondrial matrix enzyme, one of the family of glutamate dehydrogenases that are ubiquitous in life, with a key role in nitrogen and glutamate …

2024年12月25日 · This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and …

This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix Enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This …

2012年9月1日 · ATP can also inhibit mammalian GDH but with 100-fold lower affinity than GTP. Based on these enzyme properties, Smith (1979) originally proposed that mammalian GDH is …

In the beta cells, oxidation of glucose and activation of GDH by leucine increase the ratio of ATP/ADP, which leads to the closure of ATP-dependent potassium channels, the …

This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This …

Gain of function (activating) mutations on the GLUD1 gene increase GDH1 activity by rendering this isoenzyme resistant to the allosteric inhibition by GTP while retaining the stimulatory …

ADP and L-leucine, acting synergistically, modified the cooperativity curves of the two isoenzymes. Kinetic studies revealed significant differences in the K: (m) values obtained for …

Mammalian glutamate dehydrogenase1 (GDH1) (E.C. 1.4.1.3) is a mitochondrial enzyme that catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate and ammonia …

这种酶在调节氨基酸诱导的胰岛素分泌中具有重要作用。 它可以通过别构激活被ADP激活，并被GTP和ATP抑制。 这个基因中的激活突变是先天性高胰岛素血症的常见原因。 这个基因的可 …