2024年12月25日 · GLUD1 (Glutamate Dehydrogenase 1) is a Protein Coding gene. Diseases associated with GLUD1 include Hyperinsulinemic Hypoglycemia, Familial, 6 and Hyperinsulinemic Hypoglycemia, Familial, 7. Among its related pathways are GABA shunt and Glutamate and glutamine metabolism.

GLUD1 (glutamate dehydrogenase 1) is a mitochondrial matrix enzyme, one of the family of glutamate dehydrogenases that are ubiquitous in life, with a key role in nitrogen and glutamate (Glu) metabolism and energy homeostasis. This dehydrogenase is expressed at high levels in liver, brain, pancreas and kidney, but not in muscle.

2015年2月9日 · Our finding that GDH1 is upregulated in human cancers and that attenuation of GDH1 impacts cancer cell proliferation and tumor growth implicates GDH1 as a promising anticancer target. Currently, the only reported GDH1 inhibitor is epigallocatechin gallate (EGCG), a polyphenol flavonoid isolated from green tea.

GLUD1 parental protein localizes to mitochondria and the cytoplasm, GLUD2 is specifically targeted to mitochondria. GLUD1 may have a role in hyperinsulinism/hyperammonaemia syndrome; Expression, purification and characterization of human glutamate dehydrogenase (GDH) allosteric regulatory mutations

该基因编码谷氨酸脱氢酶，它是一种线粒体基质酶，可催化谷氨酸氧化脱氨生成α-酮戊二酸和氨。 这种酶在调节氨基酸诱导的胰岛素分泌中具有重要作用。 它被 ADP 变构激活并被 GTP 和 ATP 抑制。 该基因的激活突变是先天性高胰岛素血症的常见原因。 该基因的可变剪接导致多个转录变体。 人类 X 染色体上的相关谷氨酸脱氢酶 2 基因通过逆转录起源于该基因，并编码可溶形式的谷氨酸脱氢酶。 已在 10 号、18 号和 X 号染色体上鉴定出相关的假基因。 [RefSeq 提供，2016 …

2024年6月17日 · This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP.

2025年2月8日 · GluD1 regulates the connectivity of parallel fiber-interneuron synapses and promotes differentiation of interneurons. The GDH1 is a key metabolic enzyme with emerging roles in insulin regulation. MitoNEET forms a covalent complex with GDH1 through disulfide bond formation and acts as an activator.

哺乳动物谷氨酸脱氢酶1（GDH1）（EC 1.4.1.3）是一种线粒体酶，催化谷氨酸可逆氧化脱氨为α-酮戊二酸和氨，同时将NAD +和/或NADP +还原为NADH和/或NADPH。 它把氨基酸与碳水化合物的代谢联系在一起，从而促进了克雷布斯周期异常，能量产生，氨气处理和氧化还原稳态。 尽管GDH1是几十年前研究的首批主要代谢酶之一，但其在细胞生物学中的作用仍不完全清楚。 然而，人们对新型GDH2同工酶的兴趣日益浓厚，该酶通过在灵长类动物中复制而出现，并随着前 …

GLUD1 is located to chromosome 10q and encodes the isoenzyme glutamate dehydrogenase-1 (GDH1). GLUD1 is a housekeeping gene widely expressed in human tissues, including liver, kidney, pancreatic β-cells, brain, heart, intestine, spleen, skin, lymph nodes, leukocytes, fibroblasts, and placenta.

2024年10月24日 · We demonstrate that glutamine in combination with leucine activates mammalian TORC1 by enhancing glutaminolysis and α-KG production. α-KG increases the transcription of PDPK1 by reducing the suppressive histone modification H3K27me3 and then promotes the activation of the PI3K/AKT/mTOR pathway.