2024年12月25日 · This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP.

GLUD1 (glutamate dehydrogenase 1) is a mitochondrial matrix enzyme, one of the family of glutamate dehydrogenases that are ubiquitous in life, with a key role in nitrogen and glutamate (Glu) metabolism and energy homeostasis. This dehydrogenase is expressed at high levels in liver, brain, pancreas and kidney, but not in muscle.

2025年2月9日 · This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP.

Gene ID: 2746, updated on 9-Feb-2025. This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion.

2012年9月1日 · While most mammals have a single functional GLUD1 gene that is expressed widely (encoding the housekeeping GDH or hGDH1 in the human), humans and other primates have acquired a GLUD2 gene (Shashidharan et al., 1994) encoding a highly homologous isoenzyme (hGDH2) with distinct functional properties and tissue expression profile.

HGNC Approved Gene Symbol: GLUD1. L-glutamate dehydrogenase (EC 1.4.1.3) has a central role in nitrogen metabolism in plants and animals. Glutamate dehydrogenase is found in all organisms and catalyzes the oxidative deamination of 1 …

This rare genetic disease gives rise to the hyperinsulinism-hyperammonemia (HI/HA) syndrome that is caused by activating mutations in the GLUD1 gene. This gene, located on chromosome 10q23.3, is composed of 13 exons and encodes the mitochondrial enzyme glutamate dehydrogenase (GDH).

2024年6月17日 · This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This enzyme has an important role in regulating amino acid-induced insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP.

This gene encodes glutamate dehydrogenase, which is a mitochondrial matrix Enzyme that catalyzes the oxidative deamination of glutamate to alpha-ketoglutarate and ammonia. This Enzyme has an important role in regulating amino acid-induced Insulin secretion. It is allosterically activated by ADP and inhibited by GTP and ATP.

GLUD1 gene encodes the mitochondrial matrix enzyme glutamate dehydrogenase (GDH), which is expressed in the liver, renal tubules, brain and the pancreatic β-cells. It catalyzes the reversible oxidation of glutamate to α-ketoglutarate and ammonia.