GLUD1 determines murine muscle stem cell fate by controlling ...
2024年11月4日 · We found that glutamine anaplerosis into the tricarboxylic acid (TCA) cycle decreases during MuSC differentiation and coincides with decreased expression of the …
谷氨酸代谢 | Cell Signaling Technology
谷氨酰胺通过氨基酸转运蛋白 ASCT2/SLC1A5 进入细胞，并在线粒体中通过被谷氨酰胺酶 (GLS) 催化的脱氨反应转化为谷氨酸。 谷氨酸被谷氨酸脱氢酶 (GDH) 或丙氨酸或天冬氨酸转氨酶 …
Sirtuin5 contributes to colorectal carcinogenesis by enhancing ...
2018年2月7日 · Mechanistically, the direct interaction between SIRT5 and glutamate dehydrogenase 1 (GLUD1) causes deglutarylation and functional activation of GLUD1, a …
GLUD1 inhibits hepatocellular carcinoma progression via ROS
2024年1月12日 · GLUD1 functions in glutamine metabolism progress and provides α -KG for tricarboxylic acid (TCA) cycle, which is the central metabolic link which connects glucose, fatty …
Therapeutic targeting of glutamate dehydrogenase 1 that links …
2022年11月1日 · GLUD1, a key mitochondrial enzyme in glutaminolysis, is transactivated by the direct binding of leucine and converts glutamate to α-KG to enrich the TCA metabolite pool for …
Deacetylation of GLUD1 maintains the survival of lung …
2024年10月1日 · Here, we discovered that deacetylation of glutamate dehydrogenase 1 (GLUD1), one of the key enzymes in glutamine catabolism, maintains the survival of lung …
We describe that primary metabolic changes can determine murine MuSC fate decisions. We found that glutamine anaplerosis into the tricarbox-ylic acid (TCA) cycle decreases during …
GLUD1 通过控制线粒体谷氨酸水平来决定肌肉干细胞分化,bioRxiv
2023年10月4日 · 我们发现，在 MuSC 分化过程中，TCA 循环中的谷氨酰胺回补减少，并且与线粒体谷氨酸脱氨酶 GLUD1 表达的减少相一致。 增殖的 MuSC 中 Glud1 的基因缺失导致早熟分 …
GLUD1 dictates muscle stem cell differentiation by controlling ...
2023年10月5日 · We found that glutamine anaplerosis into the TCA cycle decreases during MuSC differentiation and coincides with decreased expression of the mitochondrial glutamate …
Glutamate dehydrogenase (GLUD1) expression in breast cancer
2018年11月23日 · GLUD1 is the key enzyme in the second deamination step of glutaminolysis, where it is activated by the amino acid leucine to deaminate glutamate to α-KG for …