2024年12月25日 · GNA11 (G Protein Subunit Alpha 11) is a Protein Coding gene. Diseases associated with GNA11 include Hypocalciuric Hypercalcemia, Familial, Type Ii and Hypocalcemia, Autosomal Dominant 2. Among its related pathways are Thromboxane signalling through TP receptor and Development Angiotensin activation of ERK.

14672 Ensembl ENSG00000088256 ENSMUSG00000034781 UniProt P29992 P21278 RefSeq (mRNA) NM_002067 NM_010301 RefSeq (protein) NP_002058 NP_034431 Location (UCSC) Chr 19: 3.09 – 3.12 Mb Chr 10: 81.36 – 81.38 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Guanine nucleotide-binding protein subunit alpha-11 is a protein that in humans is encoded by the GNA11 gene. Together with GNAQ ...

GNAQ and GNA11 genes encode protein members of the q class of G-protein alpha subunits involved in mediating signals between G-protein coupled receptors (GPCRs) and downstream effectors . Both genes have mainly been considered as driver genes in carcinogenesis, as they lead to constitutive activation of GPCR signalling.

The GNA11 gene provides instructions for making one component, the alpha (α) subunit, of a protein complex called a guanine nucleotide-binding protein (G protein). Learn about this gene and related health conditions.

GNA11 is involved in signalling of gonadotropin-releasing hormone receptor, which negatively regulates cell growth. Down-regulation is suggested to be involved in human breast cancers. soluble amyloid precursor protein release enhancement induced by muscarinic receptor stimulation was decreased by a G(q/11) minigene construct

2024年6月17日 · Title: In uveal melanoma Gα-protein GNA11 mutations convey a shorter disease-specific survival and are more strongly associated with loss of BAP1 and chromosomal alterations than Gα-protein GNAQ mutations.

gnaq 和 gna11 基因在几乎 80-90% 的葡萄膜黑色素瘤中以相互排斥的模式发生突变。这些基因编码异源三聚体 g 蛋白、gq 和 g11 的 α 亚基；因此，这些基因的突变会导致几个重要信号通路的激活，包括磷脂酶 c 和转录因子 yap 的激活。

2025年2月8日 · Enables G protein activity and enzyme regulator activity. Involved in several processes, including G protein-coupled receptor signaling pathway; ligand-gated ion channel signaling pathway; and positive regulation of insulin secretion.

该基因编码其中一个 alpha 亚基 (亚基 alpha-11) 。 该基因的突变与低尿钙性高钙血症 II 型 (HHC2) 和低钙血症显性 2 (HYPOC2) 相关。 HHC2 和 HYPOC2 患者分别表现出对细胞外钙浓度变化的敏感性降低或增加。 [RefSeq 提供，2013 年 12 月] The protein encoded by this gene belongs to the family of guanine nucleotide-binding proteins (G proteins), which function as modulators or transducers in various transmembrane signaling systems.

G蛋白由3个单元组成：alpha、beta和gamma。 这个基因编码alpha亚基之一（亚基alpha-11）。 这个基因的突变与Ⅱ型低钙尿性高钙血症（HHC2）和显性低钙血症2（HYPOC2）有关。 患有HHC2和HYPOC2的患者分别表现出对细胞外钙浓度变化的敏感性降低或增加。 [RefSeq提供，2013年12月] Dir./Indir. 该模块正在开发中，请耐心等待我们的数据更新。 The DNA sequence and biology of human chromosome 19. A bacterial toxin catalyzing tyrosine glycosylation of …