2024年4月10日 · G protein-coupled receptors (GPCRs) are the largest superfamily of cell surface membrane receptors and are encoded by approximately 1000 genes, sharing conserved...

2024年12月25日 · GPR88 (G Protein-Coupled Receptor 88) is a Protein Coding gene. Diseases associated with GPR88 include Chorea, Childhood-Onset, With Psychomotor Retardation and …

2022年5月2日 · GPR88 is an orphan class A G-protein-coupled receptor that is highly expressed in the striatum and regulates diverse brain and behavioral functions. Here we present...

GPR88, a brain-specific oGPCR with particularly robust expression in the striatum, regulates diverse brain and behavioral functions, including cognition, mood, movement control, and …

2022年6月2日 · MD和突变研究揭示了一组独特的结构特征和水介导的极性网络的GPR88的独特激活机制，为理解GPR88的配体结合、激活和信号传导机制提供了一个结构框架，并将促进神 …

G protein-coupled receptors (GPCRs) are the largest superfamily of cell surface membrane receptors and are encoded by approximately 1000 genes, sharing conserved seven …

g 蛋白偶联受体 88： 预计该基因编码的蛋白可实现 g 蛋白偶联光感受器活动和细胞骨架运动活动。 预计参与多个过程，包括细胞对光刺激的反应；运动学习；和光转导。

2024年4月10日 · In this study, we first review the structural advancements, activation mechanisms, and functional diversity of GPCRs. We then focus on GPCR drug discovery by …

腺苷 A1 受体拮抗剂，展示了靶向特定 GPCR 的方法。 作用于多种 GPCR 的非典型抗精神病药，体现了多靶点作用。 一种 Gi/o 型 G 蛋白抑制剂，可能会影响 GPCR 信号传导，包括 GPR …

2020年1月31日 · GPR88 is an orphan GPCR (its endogenous ligand is not known) mainly expressed in the striatum and already shown to play important roles in brain physiology. The …