G protein-coupled receptors (GPCRs), also known as seven- (pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G protein-linked receptors (GPLR), form a large group of evolutionarily related proteins that are cell surface receptors that detect molecules outside the cell and activate cellular res...

G-protein coupled receptors are involved in responses of cells to many different kinds of signals, from epinephrine, to odors, to light. In fact, a variety of physiological phenomena including vision, taste, smell and the fight-or-flight response are mediated by …

2024年4月10日 · In this study, we first review the structural advancements, activation mechanisms, and functional diversity of GPCRs. We then focus on GPCR drug discovery by revealing the detailed drug-target...

2025年1月2日 · Recent advances in X-ray crystallography, cryo-electron microscopy, spectroscopic techniques and molecular simulations have enhanced our understanding of receptor conformational dynamics and ligand...

2018年1月8日 · G-protein-coupled receptors (GPCRs) relay numerous extracellular signals by triggering intracellular signaling through coupling with G proteins and arrestins. Recent...

2024年4月1日 · General Structure and Components of GPCRs: G protein-coupled receptors (GPCRs) are integral membrane proteins characterized by seven membrane-spanning domains, commonly referred to as transmembrane helices. These structures traverse the lipid bilayer seven times, earning them the designation as 7-transmembrane receptors.

2025年2月15日 · In this review, we focus on four key metabolic GPCRs—GPR40, GPR120, GLP-1R, and β-adrenergic receptors (ADRB1, ADRB2, and ADRB3)—with respect to their roles in metabolic physiology and significance in obesity and related metabolic diseases (Figure 1). Figure 1. Overview of key GPCRs involved in the regulation of metabolic functions and diseases.

4 天之前 · The Caenorhabditis elegans neuronal GPCR OCTR-1 modulates longevity responses to both warm and cold temperatures

3 天之前 · GPCR-RTK crosstalk stimulates signaling pathways such as MAP kinase, and the activation of the GPCR-AKT signaling pathway plays a critical role in neuroblastoma progression by promoting cell growth, survival, and resistance to apoptosis through complex interactions with insulin signaling pathways.

Explore the functional significance of ICL3 in GPCR signaling, including its structural dynamics, interactions, and role in receptor regulation.