G protein-coupled receptor 55 also known as GPR55 is a G protein-coupled receptor that in humans is encoded by the GPR55 gene. [5] GPR55, along with GPR119 and GPR18, have been implicated as novel cannabinoid receptors. [6] [7]

2024年12月25日 · GPR55 is a non-CB1/CB2 receptor that exhibits affinity for endogenous, plant and synthetic cannabinoids. Originally designated an orphan receptor, GPR55 is now thought to be a functional receptor mediating the effects of ligands known to be inactive at CB1 and CB2.

GPR55 is highly expressed in large dorsal root ganglion neurons and, upon activation by various cannabinoids ( 9THC, the anandamide analog methanandamide, and JWH015) increases intracellular calcium in these neurons.

2017年4月1日 · In this review, we will focus on the role of GPR55 in energy balance and glucose metabolism. We will summarize its actions on feeding, nutrient partitioning, gastrointestinal motility and insulin secretion in preclinical models and the scarce data available in humans.

2018年1月1日 · GPR55 is a seven transmembrane spanning receptor with an extracellular N-terminal domain and an intracellular C-terminal domain (Diagram generated by Protter (Omasits et al. 2013)) Amino acid sequence alignment of mouse (NP_001028462.2), rat (XP_006245556.1), and human (NP_005674.2) GPR55 genes.

2013年4月2日 · The G-protein coupled receptor 55 (GPR55) is activated by lysophosphatidylinositols and some cannabinoids. Recent studies found prominent roles for GPR55 in neuropathic/inflammatory pain, cancer and bone physiology. However, little is known about the role of GPR55 in CNS development and function.

2014年7月30日 · GPR55. GPR55 is primarily expressed in the striatum and cerebellum but is also expressed in osteoclasts where it has been shown to regulate bone function. This receptor shares limited conserved regions with CB1 and CB2 however potential binding sites have been identified by homology modeling.

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GPR55 (gpr55_human) FAMILY. Class A (Rhodopsin) Lipid receptors GPR18, GPR55 and GPR119 GPR55 GENE. GPR55 . ORGANISM. Human (Homo sapiens) ALT. NAMES. G-protein coupled receptor 55. SOURCE. SWISSPROT. SEQUENCE.