GPR56 is expressed in liver, muscle, tendon, neural, and cytotoxic lymphoid cells in human as well as in hematopoietic precursor, muscle, and developing neural cells in the mouse. [9] GPR56 has been shown to have numerous role in cell guidance/adhesion as exemplified by its roles in tumour inhibition and neuron development.

gpr56是粘附类gpcr家族的成员，在大脑发育、免疫调节、hsc生成和肿瘤发生中具有重要功能。 GPR56在多种肿瘤类型中高表达，包括结直肠癌、乳腺癌、肝癌、胰腺癌、肺癌和卵巢癌等[21]。

2022年9月14日 · 在2022年AACR（美国癌症研究协会）会议上，GPR56首次被提及可作为结直肠癌的治疗靶点，以开发抗体-药物偶联物。 GPR56/ADGRG1是一种多功能的粘附G蛋白偶联受体，由染色体16q21上的ADGRG1基因编码的693个氨基酸组成。 GPR56转录物的广泛RNA剪接预计会产生至少五种不同的GPR56蛋白质亚型，这些GPR56受体亚型功能和信号特征各不相同。 GPR56不仅在中枢和外周神经系统、生殖系统、肌肉肥大、免疫调节和造血干细胞生成的生 …

GPR56/ADGRG1 is a versatile adhesion G protein-coupled receptor important in the physiological functions of the central and peripheral nervous systems, reproductive system, muscle hypertrophy, immune regulation, and hematopoietic stem cell ...

2024年10月1日 · Our investigation reveals a notable rise in GPR56 expression levels in human HCC cases, with heightened GPR56 levels correlating with unfavorable prognoses. GPR56 regulates TGF-β pathway by...

2015年1月21日 · Mutations in GPR56, a member of the adhesion G protein-coupled receptor family, cause a human brain malformation called bilateral frontoparietal polymicrogyria (BFPP). Magnetic resonance imaging...

2024年10月11日 · 研究团队鉴定了类固醇激素17a-hydroxypregnenolone 的膜受体GPR56与铁死亡密切相关，该研究首次揭示了17-OH PREG-GPR56-CD36 轴介导的脂质代谢是一种新的抗铁死亡途径，其介导的信号转导是维持肝脏稳态的必要条件，为临床肝脏损伤中的治疗方法的开发和应 …

Therefore, in this review, we will summarize the latest findings of GPR56 function in neurological and psychiatric disorders (depression, epilepsy, autism, and BFPP) and emphasize the mechanisms of GPR56 in activation and signalling in those conditions.

2024年11月5日 · Lin et al. demonstrated that GPR56, a G-protein-coupled receptor, can be activated by its agonist to suppress ferroptosis-a form of cell death-and effectively mitigate ferroptosis-associated liver damage.

2024年9月25日 · GPR56, encoded by ADGR1, is a multifunctional adhesion GPCR involved in a long range of biological processes, including oligodendrocyte and brain development, hematopoietic stem cell generation, myoblast fusion and muscle hypertrophy, adipogenesis, testis development, immunoregulation, and tumorigenesis .