Granzyme B (GrB) is a pro-apoptotic serine protease that contributes to immune-mediated target cell apoptosis. However, during inflammation, GrB accumulates in the extracellular space, retains its activity, and is capable of cleaving extracellular matrix (ECM) proteins.

2021年3月30日 · The objective of this study was to identify proteoglycan (PG) substrates of GrB and examine the ability of GrB to release PG-sequestered TGF-β1 into the extracellular milieu.

2020年11月2日 · We aimed to investigate a cytotoxic immune response by measuring granzyme B (GrB) in peripheral blood mononuclear cells (PBMC) in patients affected with ovarian or lung malignancy, with and without accompanying PNS. We enrolled patients with: nonmalignant lesions (n = 21), ovarian cancer (n = 19), lung cancer (n = 57), and PNS (n = 30).

Granzyme B (GrB) is a serine protease secreted, along with pore-forming perforin, by cytotoxic lymphocytes to mediate apoptosis in target cells. GrB has been detected in tumor cells associated with systemic and breast implant–associated anaplastic ...

We aimed to investigate a cytotoxic immune response by measuring granzyme B (GrB) in peripheral blood mononuclear cells (PBMC) in patients affected with ovarian or lung malignancy, with and without accompanying PNS. Methods: We enrolled patients with: nonmalignant lesions (n = 21), ovarian cancer (n = 19), lung cancer (n = 57), and PNS (n = 30).

1998年4月1日 · Low levels of GrA and GrB were present in plasma of healthy individuals (GrA, 33.5 pg/ml (median); GrB, 11.5 pg/ml (median)), whereas significantly higher levels were present in patients with ongoing CTL response, i.e., patients suffering from …

Mean levels of GrB in the plasma and synovial fluid of rheumatoid arthritis patients have been reported to be as high as 1 ng/ml and 3 ng/ml respectively (compared to ,40 pg/ml in healthy patients), and similar increases of GrB in bodily fluids have

2018年12月24日 · 本文详细介绍如何使用Python的pygrib库读取grib/grib2格式的气象数据，包括头文件信息读取、数据读取及写入txt和csv文件的方法。 同时，提供了变量读取的具体实例。 一般利用NCL (NCAR Command Language)读取。 利用Python语言的pygrib库也可以读取grib/grib2格式数据. fnl再分析资料的数据格式有netcdf 和grib grib2 这几种数据格式，用于WRF读取的为grib grib2格式的，所以一般下载grib格式的数据。 其中，grib1 的数据从1999年7月30日-2007 …

We found that T2D patients had serum levels of GrB significantly higher than the control group (10.17 ± 12.6 vs 7.2 ± 14.1 pg/ml, p = 0.03). Moreover, in T2D patients increased GrB correlated with unfavorable inflammatory profile, as described by elevated levels of validated adipokines such as IL-6 (p = 0.04), TNF-α (p = 0.019) and WISP1 (p ...

2010年2月11日 · GrB-secreting pDCs may play a regulatory role for immune evasion of tumors, antiviral immune responses, and autoimmune processes. Our results provide novel information about the complex network of pDC–T-cell interactions and may contribute to an improvement of prophylactic and therapeutic vaccinations.