葡萄糖调节蛋白94(glucose-regulated protein 94，GRP94)是分子伴侣热激蛋白90(heat shock protein 90，Hsp90)的内质网亚型。 生理条件下，它在调节生物生理功能方面起着协助膜蛋白折叠、维持钙稳态以及调节免疫系统功能的重要作用。

grp94 has been shown to be a target for treatment of a plethora of diseases such as glaucoma, multiple myeloma, and metastatic cancer. grp94 includes 5 distinct amino acids in its primary sequence which creates 2 unique sub-pockets, S1 and S2.

2012年3月1日 · GRP94 is an endoplasmic reticulum resident chaperone that belongs to HSP90 family. GRP94 chaperones secreted and membrane proteins. GRP94 is essential in development and physiology of multi-cellular organisms. GRP94 shares biochemical features with HSP90 but displays distinct activities.

2024年5月29日 · Here, we show that GRP94 was involved in β cell adaption and compensation (or failure) in islets from leptin receptor-deficient (db/db) mice in an age-dependent manner. GRP94-deficient cells...

2019年10月2日 · 葡萄糖调节蛋白94（GRP94）是内质网应激的标志蛋白，并通过内质网信号途径调控细胞凋亡的发生。 本文主要就GRP94及其互作蛋白对内质网应激诱导的肝细胞凋亡的调控机制，及GRP94在肝疾病中如何发挥作用进行综述，以期为畜牧上引起内质网应激的生产条件调控以及临床上与内质网应激相关细胞凋亡的肝病治疗提供参考。 Abstract: Intracellular endoplasmic reticulum stress (ERS) is ubiquitous in the widespread stress response of livestock, poultry …

2021年1月22日 · In this work, we studied GRP94 in M1/LPS + IFNγ and M2/IL-4 primary macrophages derived from human monocytes (isolated from buffy coats), in basal and ER stress conditions induced by thapsigargin...

2018年1月1日 · Grp94 is the endoplasmic reticulum (ER) paralog of heat shock protein (Hsp) 90. This chaperone/stress protein belongs to the protein family of glucose-regulated proteins (Grp), whose levels increase in mammalian cell cultures in the absence of glucose.

2021年3月17日 · Glucose-regulated protein 94 (GRP94) is an endoplasmic reticulum (ER)-resident member of the heat shock protein 90 (HSP90) family. In physiological conditions, it plays a vital role in regulating biological functions, including chaperoning cellular proteins in the ER lumen, maintaining calcium homeo …

GRP94 and IGFs play a specific role in alleviating ER-stress: GRP94 is essential for production of IGF. Autocrine/paracrine IGF signaling can delivers both anti-apoptotic and pro-recovery signals. In addition, IGF signaling also potentiates an existing UPR, which in turn can control IGF signaling either positively or negatively.

Clinically, expression of GRP94 correlates with advanced stage and poor survival in a variety of cancers. Recent preclinical studies have also revealed that GRP94 expression is closely linked to cancer growth and metastasis in melanoma, ovarian cancer, multiple myeloma, lung cancer, and inflammation-associated colon cancer.