Inhibition of MEK/ERK upregulates GSH production and increases …
2020年3月20日 · Our results suggested that inhibition of the ERK pathway may promote OC differentiation via upregulation of GSH. These findings reveal that ERK and GSH modulate the …
MMP-2/GSH-responsive nanobomb for tumor chemo
2024年7月1日 · Re-educating TAMs to M1-like by regulating ERK/MAPK via HBEGF. This nanosystem generates robust antitumor effect via chemo-immunotherapy. The low targeting of …
抑制 MEK/ERK 上调 GSH 产生并增加 RANKL 诱导的 RAW 264.7 细 …
我们的结果表明抑制 erk 通路可能促进 oc 分化通过上调 gsh。这些发现表明 erk 和 gsh 调节了 oc 分化所必需的信号通路，这可能构成治疗 oc 相关疾病的新治疗策略的基础。
Rosmarinic Acid Inhibits Ultraviolet B-Mediated Oxidative Damage …
2024年1月1日 · These results suggest that RA protects against UVB-induced oxidative damage by activating AKT and ERK signaling to regulate NRF2 signaling and enhance GSH …
Selective and persistent activation of extracellular signal-regulated ...
2003年12月1日 · Intracellular glutathione (GSH) levels determine whether nitric oxide (NO) is neurotrophic for dopamine neurons or triggers a cell death cascade in primary midbrain …
褪黑素通过调节Erk / Akt / NFkB途径改善H2O2诱导的 ... - X-MOL
2018年6月13日 · 酶促和非酶促抗氧化剂，例如丙二醛（mda），超氧化物歧化酶（sod），用分光光度法测量过氧化氢酶（cat）和谷胱甘肽（gsh）。 还通过蛋白质印迹分析测量了热休克蛋 …
Targeting the MAPK/ERK and PI3K/AKT Signaling Pathways …
2020年7月17日 · The mitogen-activated protein kinase (MAPK)/extracellular signal kinase (ERK) and phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) signal transduction pathways …
Prolonged exposure to environmental levels of ... - ScienceDirect
2023年11月15日 · Moreover, MC-LR exposure induced a notable elevation of p-ERK levels both in vivo and in vitro. Furthermore, treatment with an ERK inhibitor partially restored cell viability, …
高良姜素激活 ERK/AKT 驱动的 Nrf2 信号通路以增加人角质形成细 …
在这项研究中，我们研究了高良姜素对参与还原型谷胱甘肽 (GSH) 合成的抗氧化酶的诱导作用，并研究了相关的上游信号级联。 通过激活核因子-红细胞 2 相关因子 (Nrf2)，高良姜素处理显着 …
The mechanism of thia-Michael addition catalyzed by LanC enzymes
We present herein crystal structures of human LanCl1 bound to methyl GSH (1.58 Å resolution) or to the product of GSH addition to a Dhb-containing peptide that mimics the activation loop of …