
Grape Seed Proanthocyanidin Ameliorates LPS-induced Acute …
Using H&E staining, flow cytometry, and ELISA, we found that GSP attenuated LPS-induced lung pathological changes and decreased inflammatory cytokine expression in ALI mice. In addition, GSP reduced the recruitment of monocyte-derived macrophages to the lung and significantly promoted the polarization of primary mouse lung macrophages from M1 ...
Grape Seed Proanthocyanidin Ameliorates LPS-induced Acute
2023年8月11日 · Grape seed proanthocyanidin (GSP) has received much attention over several decades, and many biological activities such as anti-apoptotic, antioxidant, and anti-inflammatory have been identified. This study aimed to determine the effect of GSP on lipopolysaccharide (LPS)-induced ALI.
Grape Seed Proanthocyanidin Ameliorates LPS-induced Acute …
Grape seed proanthocyanidin (GSP) has received much attention over several decades, and many biological activities such as anti-apoptotic, antioxidant, and anti-inflammatory have been identified. This study aimed to determine the effect of GSP on …
科研丨IJBM: 桑葚多糖通过调节肠道菌群和TLR4/NF-κB通路介导的 …
2023年9月6日 · lps是激活nf-κb的上游因子之一,可被tlr4特异性识别,通过两条传导途径(myd88依赖和非myd88依赖途径)触发分子信号级联,最终促进nf-κb的核易位,调节多种炎症因子的表达。
<br>葡萄籽原花青素通过 TREM2/PI3K/Akt 通路调节 M2a 巨噬细胞极化,改善 LPS …
通过 h&e 染色、流式细胞术和 elisa,我们发现 gsp 可以减轻 ali 小鼠中 lps 诱导的肺部病理变化并降低炎症细胞因子的表达。 此外,GSP 减少了单核细胞来源的巨噬细胞向肺部的募集,并显着促进了 LPS 诱导的原代小鼠肺巨噬细胞从 M1 到 M2a 的极化。
Anti-inflammatory effect of lipophilic grape seed …
2020年12月1日 · In order to enhance the lipophilicity of GSP for improved bio-efficiency, lipophilic grape seed proanthocyanidin (LGSP) was synthesized by enzymatic esterification of GSP. The anti-inflammatory activity of LGSP was evaluated in lipopolysaccharides-stimulated RAW 264.7 cells in vitro and a zebrafish tail-amputated model in vivo.
Grape seed proanthocyanidin (GSP) has received much attention over several decades, and many biological activities such as anti-apoptotic, antioxidant, and anti-inflammatory have been identified. This study aimed to determine the effect of GSP on …
Grape Seed Proanthocyanidin Alleviates Intestinal Inflammation …
2022年1月28日 · In this study, GSP alleviated intestinal inflammation induced by LPS and altered the gut microbiota accompanied by increased abundance of hydroxysteroid dehydrogenase (HSD) producing microbes.
GSP-2, a polysaccharide extracted from Ganoderma sinense, is a …
To investigate GSP-2 dose-response effects on TLR4 activation, we incubated mTLR4 cells with increasing GSP-2 concentrations in the presence of PMB (10 μg/ml), to rule out possible effects due to LPS contamination. A 18-h treatment with GSP-2 significantly stimulated mTLR4 cells in a dose-dependent manner .
Box-Behnken响应面;葡萄籽原花青素柔质体(GSP-LPs);体外释放
目的 优化葡萄籽原花青素柔质体(grape seed proanthocyanidins flexiblenano-liposomes,GSP-LPs)的制备工艺,评价其体外释放及透皮释放能力.方法 采用薄膜分散超声法制备GSP-LPs,以包封率、粒径、电位、PDI值为指标,在查阅文献和单因素实验的基础上,用响应曲面法优化葡萄籽原 ...