Using H&E staining, flow cytometry, and ELISA, we found that GSP attenuated LPS-induced lung pathological changes and decreased inflammatory cytokine expression in ALI mice. In addition, GSP reduced the recruitment of monocyte-derived macrophages to the lung and significantly promoted the polarization of primary mouse lung macrophages from M1 ...

2023年8月11日 · Grape seed proanthocyanidin (GSP) has received much attention over several decades, and many biological activities such as anti-apoptotic, antioxidant, and anti-inflammatory have been identified. This study aimed to determine the effect of GSP on lipopolysaccharide (LPS)-induced ALI.

Grape seed proanthocyanidin (GSP) has received much attention over several decades, and many biological activities such as anti-apoptotic, antioxidant, and anti-inflammatory have been identified. This study aimed to determine the effect of GSP on …

2023年9月6日 · lps是激活nf-κb的上游因子之一，可被tlr4特异性识别，通过两条传导途径(myd88依赖和非myd88依赖途径)触发分子信号级联，最终促进nf-κb的核易位，调节多种炎症因子的表达。

通过 h&e 染色、流式细胞术和 elisa，我们发现 gsp 可以减轻 ali 小鼠中 lps 诱导的肺部病理变化并降低炎症细胞因子的表达。 此外，GSP 减少了单核细胞来源的巨噬细胞向肺部的募集，并显着促进了 LPS 诱导的原代小鼠肺巨噬细胞从 M1 到 M2a 的极化。

2020年12月1日 · In order to enhance the lipophilicity of GSP for improved bio-efficiency, lipophilic grape seed proanthocyanidin (LGSP) was synthesized by enzymatic esterification of GSP. The anti-inflammatory activity of LGSP was evaluated in lipopolysaccharides-stimulated RAW 264.7 cells in vitro and a zebrafish tail-amputated model in vivo.

Grape seed proanthocyanidin (GSP) has received much attention over several decades, and many biological activities such as anti-apoptotic, antioxidant, and anti-inflammatory have been identified. This study aimed to determine the effect of GSP on …

2022年1月28日 · In this study, GSP alleviated intestinal inflammation induced by LPS and altered the gut microbiota accompanied by increased abundance of hydroxysteroid dehydrogenase (HSD) producing microbes.

To investigate GSP-2 dose-response effects on TLR4 activation, we incubated mTLR4 cells with increasing GSP-2 concentrations in the presence of PMB (10 μg/ml), to rule out possible effects due to LPS contamination. A 18-h treatment with GSP-2 significantly stimulated mTLR4 cells in a dose-dependent manner .

目的 优化葡萄籽原花青素柔质体(grape seed proanthocyanidins flexiblenano-liposomes,GSP-LPs)的制备工艺,评价其体外释放及透皮释放能力.方法 采用薄膜分散超声法制备GSP-LPs,以包封率、粒径、电位、PDI值为指标,在查阅文献和单因素实验的基础上,用响应曲面法优化葡萄籽原 ...