2024年12月25日 · GAB1 (GRB2 Associated Binding Protein 1) is a Protein Coding gene. Diseases associated with GAB1 include Deafness, Autosomal Recessive 26 and Glioblastoma. Among its related pathways are Downstream signaling of activated FGFR2 and Insulin receptor signalling cascade.

GRB2-associated-binding protein 1 is a protein that in humans is encoded by the GAB1 gene. [5] The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family.

2003年3月11日 · Grb2-associated binder-1 (Gab1) is a pleckstrin homology (PH) domain-containing adapter molecule that is believed to function downstream of receptors for growth factors...

Gab1 is a multiadaptor protein that has been shown to be required for multiple processes in embryonic development and oncogenic transformation. Gab1 functions by amplifying signal transduction downstream of various receptor tyrosine kinases through ...

2019年10月24日 · Grb2-associated binder (Gab) family proteins are multi-site docking proteins, which expand cytokine-induced signal transduction in a spatial- and time-dependent manner by coordinating the recruitment of proteins involved in mitogen activated protein kinase (MAPK)/extracellular-signal regulated kinase (ERK) and phosphatidyl-inositol-3-kinase (PI3...

蛋白包括Gab1、Gab2和Gab3。 该家族蛋白可通过介导膜受体与信号转导蛋白间的耦联及各信号分子间的相互作用参与信号 转导，其主要是通过激活SHP2/RAS/ERK和PI3K/AKT两条经典的信号通路，进而参与一系列的生物应答。

2025年2月8日 · Gab1 is essential regulator of the hair cycle and the self-renewal of hair follicle stem cells. Data show that guanine nucleotide-binding protein G (i) subunit alpha-1 and alpha-3 (Galphai1/3) can interact with CD14 antigen/Grb2-associated binding protein Gab1, which modulates macrophage polarization in vitro and in vivo.

2012年2月25日 · Gab1 在小鼠的胚胎期就开始表达，利用基因敲除研究 Gab1 的基因功能发现，Gab1 基因敲除小鼠于胚胎期 1 5～17 5 d 死 亡，并表现出胎盘、心脏、皮肤等多器官发育障碍，其异常的表现

《Gab1在调节器官发育过程和癌症中的作用》是依托上海交通大学，由杨自强担任项目负责人的青年科学基金项目。 正常发育中，细胞在生长因子及细胞因子的调控下极化并组装成复杂的结构，比如乳腺，肺，肾脏等器官和组织中的树枝状管状结构。 然而在疾病发生中，细胞极化的机制被破坏。 细胞极化是由细胞外生长因子和细胞内蛋白复合物（比如PAR蛋白质）协同调控的。 但是生长因子是如何与细胞内极性调节复合物联系在一起的直到最近还不清楚。 我近期的研究首先回 …

该基因编码的蛋白质是 IRS1 样多底物对接蛋白家族的成员。 它是分支小管发生的重要介质，在细胞生长反应、转化和细胞凋亡中起着核心作用。 已发现该基因的两个转录本变体编码不同的亚型。 [RefSeq 提供，2008 年 8 月] The protein encoded by this gene is a member of the IRS1-like multisubstrate docking protein family.