Growth arrest and DNA-damage-inducible protein GADD45 alpha is a protein that in humans is encoded by the GADD45A gene. [5][6][7] This gene is a member of a group of genes, the GADD45 genes, whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents (mutagens).

2024年12月25日 · GADD45A (Growth Arrest And DNA Damage Inducible Alpha) is a Protein Coding gene. Diseases associated with GADD45A include Pancreatic Adenocarcinoma and Xeroderma Pigmentosum, Variant Type. Among its related pathways are Endometrial cancer and Gene expression (Transcription).

近日， Xavier Palomer等学者的最新研究成果GADD45A: With or without you 发表于 Med Research Reviews，研究团队深入讨论了GADD45家族中的关键成员—— GADD45A，文章深入探讨了其在癌症、代谢、神经退行性疾病和心血管疾病中的作用，以及它如何作为治疗这些疾病的潜在靶点。 论文通过文献综述的方式，分析了现有的研究成果，探讨了GADD45A在不同疾病背景下的功能和调控机制，它就像故事里的“超级英雄”，守护着我们的健康。 上图展示了GADD45A …

Gadd45a, encodes a ubiquitously expressed protein that is often induced by DNA damage and other stress signals associated with growth arrest and apoptosis. (Review) Gadd45a levels are significantly associated with hormone receptor status in human breast cancer

2021年7月16日 · GADD45 proteins mediate DNA repair in different cells including keratinocytes. In the immune system, GADD45a and GADD45b regulate the function and activation of both T lymphocytes and dendritic...

The first identified Gadd45 gene, Gadd45a, encodes a ubiquitously expressed protein that is often induced by DNA damage and other stress signals associated with growth arrest and apoptosis. This protein and the other two members of this small gene family, Gadd45b and Gadd45g, have been implicated in …

该基因是一组基因的成员，其转录水平在应激生长停滞条件和 DNA 损伤剂处理后增加。 由该基因编码的蛋白质通过 MTK1/MEKK4 激酶介导 p38/ JNK 通路的激活来响应环境压力。 该基因的 DNA 损伤诱导转录由 p53 依赖性和非依赖性机制介导。 已为该基因发现编码不同亚型的可变剪接转录物变体。 [RefSeq 提供，2010 年 12 月] This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with …

2024年1月24日 · The growth arrest and DNA damage inducible (GADD)45 family includes three small and ubiquitously distributed proteins (GADD45A, GADD45B, and GADD45G) that regulate numerous cellular processes associated with stress signaling and injury response. Here, we provide a comprehensive review of the current …

2022年5月4日 · GADD45 is a gene family consisting of GADD45A, GADD45B, and GADD45G that is often induced by DNA damage and other stress signals associated with growth arrest and apoptosis. Many of these roles are carried out via signaling mediated by p38 mitogen-activated protein kinases (MAPKs).

GADD45a基因的全称是生长阻滞与DNA损伤基因(growth arrest and DNA damage,GADD),该基因又叫做DNA损伤诱导基因(DNA damage inducible transcript 1,DDIT)GADD45a基因染色体全长3278bp,而mRNA的全长为1355 bp,一共有4个外显子,编码序列全长为498 bp,该基因一共编码了165个氨基酸的蛋白,蛋白 ...