GARP-TGF-β1丨双面间谍TGF-β的下一代继任者 - 药时代DrugTimes
2022年3月16日 · GARP是一种I型跨膜细胞表面对接蛋白，用于潜伏性转化生长因子-β1（TGF-β1）在活化的调节性T淋巴细胞、活化的B细胞和血小板上的表达。 GARP调节TGF-β1的定位 …
肿瘤免疫抑制微环境的扳手-GARP - 知乎 - 知乎专栏
hlx-60是一款garp单抗，可阻断tgf-β1的释放，从而减小tgf-β1的免疫抑制作用；同时，还可以引发adcc效应，清除garp+ treg。 2022年8月26日，HLX-60与PD-1单抗联用于实体瘤患者的I期临 …
GARP regulates the bioavailability and activation of TGFβ
Glycoprotein-A repetitions predominant protein (GARP) associates with latent transforming growth factor-β (proTGFβ) on the surface of T regulatory cells and platelets; however, whether GARP …
Monoclonal antibodies against GARP/TGF-β1 complexes inhibit …
Two anti-GARP monoclonal antibodies were generated that block the production of active TGF-β1 by human T regs. These antibodies recognize a conformational epitope that requires amino …
GARP: a surface molecule of regulatory T cells that is involved in …
Two anti-GARP monoclonal antibodies recognize a conformational epitope within GARP-mTGF-β complex and block the production of active TGF-β from human Tregs. The two antibodies can …
Selective inhibition of TGF-β1 produced by GARP-expressing …
2020年9月11日 · In human melanoma samples infiltrated by T cells and GARP-expressing Tregs, we found evidence of TGF-β signaling within the T cell compartment, suggesting that blockade …
Immunoregulatory functions and the therapeutic implications of GARP-TGF …
2018年2月20日 · GARP (glycoprotein-A repetitions predominant) is a type I transmembrane cell surface docking receptor for latent transforming growth factor-β (TGF-β) that is abundantly …
Membrane protein GARP is a receptor for latent TGF-beta on the …
Membrane localization of latent TGF-beta mediated by binding to GARP may be necessary for the ability of Treg to activate TGF-beta upon TCR stimulation. However, it is not sufficient as …
Structural basis of latent TGF-β1 presentation and activation by GARP …
2018年10月25日 · Regulatory T cells (T regs) suppress immune cells within close proximity by activating latent TGF-β1 presented by GARP (glycoprotein A repetitions predominant) to …
Targeting GARP–TGF-β1 with livmoniplimab plus anti–PD-1 …
2024年5月29日 · Data from mouse models demonstrated that combined targeting of GARP–TGF-β1 and PD-1 improved antitumor effects compared with anti–PD-1 alone (3). Livmoniplimab …