Germinal center kinases in immune regulation - Nature
2012年9月10日 · Germinal center kinases (GCKs) are a family of ‘Sterile 20 (STE20) like kinases’, which participate in both the determination of cell fate and the regulation of cell...
GCK Gene - GeneCards | HXK4 Protein | HXK4 Antibody
2024年12月25日 · GCK (Glucokinase) is a Protein Coding gene. Diseases associated with GCK include Hyperinsulinemic Hypoglycemia, Familial, 3 and Maturity-Onset Diabetes Of The Young, Type 2. Among its related pathways are glycolysis (BioCyc) and …
Targeting the GCK pathway: a novel and selective therapeutic strategy ...
2021年4月1日 · We identified germinal center kinase (GCK) as a novel therapeutic target in MM with RAS mutation. GCK knockdown (KD) in MM cells demonstrated in vitro and in vivo that silencing of GCK induces MM cell growth inhibition, associated with blocked MKK4/7-JNK phosphorylation and impaired degradation of IKZF1/3, BCL-6, and c-MYC.
Germinal center kinases (GCKs) compose a subgroup of the Ste20 family of kinases. Here we describe the cloning and characterization of a novel GCK family ki-nase, Traf2- and Nck-interacting kinase (TNIK) that in-teracts with both Traf2 and Nck. TNIK encodes. eric G proteins coupled to pheromone receptors (1).
Signaling by the Germinal Center Kinase Family of Protein Kinases
Recently, protein Ser/Thr kinases related to human germinal center kinase (GCK) have emerged as important potential players in the regulation of stress-activated MAPK core signaling pathways. This review will discuss what is known about the GCKs …
The germinal center kinase GCK-1 is a negative regulator of
2009年10月14日 · The germinal center kinases (GCK) constitute a large, highly conserved family of proteins that has been implicated in a wide variety of cellular processes including cell growth and proliferation, polarity, migration, and stress responses. Although diverse, these functions have been attributed to an …
Germinal center kinase is required for optimal Jun N-terminal …
Germinal center kinase (GCK), a member of the Ste20 family, selectively activates the Jun N-terminal kinase (JNK) group of mitogen-activated protein kinases. Here, we show that endogenous GCK is activated by polyinosine-polycytidine [poly (IC)] and lipopolysaccharides (LPS), lipid A, interleukin-1 (I …
The GCK II and III subfamilies of the STE20 group kinases
2007年2月1日 · Phylogenetic relationship of GCKII and III subfamily of kinases. Shown are human proteins, and proteins from D. melanogaster (Dm), C. elegans (Ce), D. discoideum (Dd), and S. pombe (Sp). The...
NESK, a Member of the Germinal Center Kinase Family That …
2000年7月7日 · The germinal center kinase (GCK) 1 family is a subfamily of the Ste20 family of protein kinases ( 1 ). GCK family members have an N-terminal kinase domain and a C-terminal regulatory domain. The GCK family is divided into two structurally and functionally distinct groups ( …
Germinal center kinases in immune regulation - PMC
2012年9月10日 · Germinal center kinases (GCKs) are a family of ‘Sterile 20 (STE20) like kinases', which participate in both the determination of cell fate and the regulation of cell functions. Functions of GCKs are linked with human diseases including cancer and immunological disorders.