2024年9月8日 · Glucokinase (GCK) is a member of the hexokinase family, also known as hexokinase IV. It plays an essential role in glucose metabolism, crucial for sustaining blood …

MODY 2 or GCK-MODY is a form of maturity-onset diabetes of the young. [1] It is due to any of several mutations in the GCK gene on human chromosome 7 for glucokinase. [2] Glucokinase …

2007年1月1日 · In this review we will focus on two subfamilies of the group, GCK-II and GCK-III, families that are closely related but, again, unique in their structural features and biological …

2019年3月15日 · Glucokinase (GCK, hexokinase IV) is a monomeric enzyme that catalyzes the ATP-dependent conversion of glucose to glucose 6-phosphate, the first and rate-limiting step …

2012年9月10日 · GCK-I kinases are mitogen-activated protein kinase (MAPK) kinase kinase kinases that are termed MAP4Ks. GCK-I kinases can activate extracellular signal-regulated …

2024年9月8日 · Glucokinase (GCK), a key enzyme in glucose metabolism, plays a central role in glucose sensing and insulin secretion in pancreatic β-cells, as well as glycogen synthesis in …

Among the hexokinases, GCK displays unique enzyme kinetics in two respects. First, GCK has an affinity for glucose (S 0.5 ≅ 6 mM) more than 20 times lower than that of the next ranking …

In this review we will focus on two subfamilies of the group, GCK-II and GCK-III, families that are closely related but, again, unique in their structural features and biological functions. Herein, …

2024年9月8日 · 葡萄糖激酶 (gck) 是葡萄糖代谢中的关键酶，在胰腺 β 细胞的葡萄糖感应和胰岛素分泌以及肝脏中的糖原合成中发挥着核心作用。 GCK 基因突变与各种单基因糖尿病 (MD) 疾 …

2012年9月10日 · GCK-I kinases regulate NF-κB activation, integrin activity, pathogen-associated molecular pattern signaling and inflammation. GCK-I kinases are mitogen-activated protein …