Glucokinase regulatory protein: complexity at the crossroads of ...
Glucokinase regulator (GCKR) encodes glucokinase regulatory protein (GKRP), a hepatocyte-specific inhibitor of the glucose-metabolizing enzyme glucokinase (GCK). Genome-wide …
GCKR - ScienceDirect
2022年11月1日 · Using detailed genotype-phenotype data from the Hong Kong Diabetes Register (HKDR) with over 15-year follow up, we investigated associations of the GCKR polymorphism …
关于葡萄糖激酶和葡萄糖激酶调节蛋白在糖尿病中的作用的最新见 …
大量研究表明，GKRP 功能障碍并不是高甘油三酯血症的唯一原因，这意味着可以通过小分子 GKRP 抑制激活肝脏特异性 GCK 来治疗 2 型糖尿病。 该综述强调了目前关于葡萄糖激酶和 …
GCKR and GCK polymorphisms are associated with increased risk …
Aims: Glucokinase (GCK) and glucokinase regulatory protein (GKRP) regulate glucose and lipid metabolism. We investigated the associations of GCKR and GCK polymorphisms with kidney …
Interaction Effect of Genetic Polymorphisms in Glucokinase
2009年3月1日 · GCKR is a rate-limiting factor of glucokinase (GCK), which functions as a key glycolytic enzyme for maintaining glucose homeostasis. We examined the associations of two …
Interaction Effect of Genetic Polymorphisms in Glucokinase (GCK) …
GCKR is a rate-limiting factor of glucokinase (GCK), which functions as a key glycolytic enzyme for maintaining glucose homeostasis. We examined the associations of two common genetic …
GCKR基因rs780094 (C>T)多态性与妊娠期糖尿病发病风险的相关性 …
GCKR 基因rs780094 (C>T)多态性基因型频率，采用实时荧光定量PCR法进行检测。 采用成组 t 检验，对2组孕妇人体质量指数 (BMI)，总胆固醇 (TC)、高密度脂蛋白胆固醇 (HDL-C)、低密度 …
GCKR-P446L 基因变异在 P446L 小鼠中易导致血液胆固醇升高和血糖降低 - GCKR …
目标 由GCKR编码的葡萄糖激酶调节蛋白 GKRP能够对肝脏葡萄糖激酶进行急性调节，以支持代谢需求。 大型连锁不平衡区域内常见的人类GCKR rs1260326:Pro446 > Leu 变体与多效性特征 …
GCKR - Diabetes Research and Clinical Practice
2022年8月31日 · Glucokinase (GCK) and glucokinase regulatory protein (GKRP) regulate glucose and lipid metabolism. We investigated the associations of GCKR and GCK polymorphisms …
An Exome-Chip Association Analysis in Chinese Subjects …
2017年4月6日 · Single-variant association analysis interrogating 70,444 single nucleotide polymorphisms identified a novel locus, GCKR, significantly associated with circulating FGF21 …