2024年12月25日 · GCN1 (GCN1 Activator Of EIF2AK4) is a Protein Coding gene. Diseases associated with GCN1 include Ogden Syndrome and Pulmonary Interstitial Emphysema. …

Gcn1-ribosome co-sedimentation assays suggest that Gcn20 modulates the affinity of Gcn1 to the ribosome, supporting the idea that Gcn20 fine-tunes Gcn1-ribosome interaction in response to …

2023年1月12日 · GCN1 is a conserved ribosome-associated scaffolding protein that binds the RWD domain of the integrated stress response kinase, GCN2. 46, 47 In addition, GCN1 was …

2024年6月1日 · GCN1 is a highly conserved protein present widely across eukaryotes. As an upstream activator of protein kinase GCN2, GCN1 plays a pivotal role in integrated stress …

2023年6月19日 · GCN1 then recruits CCR4/NOT and other quality control factors, shaping global mRNA turnover. These results position GCN1 as a key translational regulator of proteostasis, …

2025年2月9日 · These findings suggest that GCN1 can regulate eIF2alpha phosphorylation in HSV-1-infected cells and that the GCN1-binding viral partner simplexvirus gH is necessary …

2020年4月23日 · Here, we show that GCN1 is involved in GCN2-mediated eIF2α phosphorylation after AAS and UV radiation by generating Gcn1 mutant mice. Interestingly, GCN1 not only …

2020年4月23日 · GCN1 is a GCN2-binding protein that possesses an RWD binding domain (RWDBD) in its C-terminus. In yeast, Gcn1 is essential for Gcn2 activation by AAS; however, …

6 天之前 · Background General control non-derepressible protein 1 (GCN1), a ribosome-binding protein, has been implicated in the development and progression of multiple cancers. …

2024年3月5日 · We propose that GCN1 regulates ribosome-mediated signaling by dynamically changing its partners among RWD domain-possessing proteins via unknown mechanisms. We …