Exploring the multifaceted role of GCN1: Implications in cellular ...
2024年6月1日 · In response to cellular stress, GCN1 orchestrates the activation of GCN2, thereby initiating subsequent ISR pathways crucial for maintaining cellular homeostasis. Moreover, …
Structure of Gcn1 bound to stalled and colliding 80S ribosomes
2021年3月31日 · Here we illustrate how a single protein can monitor both ribosomes within a disome, by presenting a cryo-electron microscopy structure of a native complex of the ISR …
The integrated stress response in metabolic adaptation - PMC
A recent mouse knockout study has provided added insights regarding the relationship between GCN1 and GCN2. As expected, GCN1 KO mouse fibroblasts could not induce ISR in …
GCN1 Gene - GeneCards | GCN1 Protein | GCN1 Antibody
2024年12月25日 · GCN1 also acts as a positive activator of the integrated stress response (ISR) by mediating activation of EIF2AK4/GCN2 in response to amino acid starvation (By similarity). …
Mechanisms of readthrough mitigation reveal principles of GCN1 …
2023年6月19日 · GCN1 was initially shown to sense uncharged tRNAs at the ribosome A-site upon amino acid starvation, resulting in eIF2α phosphorylation via GCN2 kinase 26 and global …
Structure of Gcn1 bound to stalled and colliding 80S ribosomes
2021年4月1日 · The Gcn pathway is conserved in all eukaryotes, including mammals such as humans, where it is a crucial part of the integrated stress response (ISR). Gcn1 serves as an …
Ribosome binding protein GCN1 regulates the cell cycle and …
2020年4月23日 · Here, we show that GCN1 is involved in GCN2-mediated eIF2α phosphorylation after AAS and UV radiation by generating Gcn1 mutant mice. Interestingly, GCN1 not only …
Multiprotein bridging factor 1 is required for robust activation of …
2024年11月19日 · Our biochemical and structural analyses reveal that Mbf1 functions as a core ISR factor by interacting with collided ribosomes to mediate Gcn2 activation. We further show …
Emerging Role of GCN1 in Disease and Homeostasis - MDPI
2024年3月5日 · The GCN1–GCN2 pathway mediates the integrated stress response (ISR). In response to various stressors, eIF2α phosphorylation by stress-specific kinases attenuates …
Mol Cell | Ribo-seq应用：揭秘整合应激反应如何调控哺乳动物 …
2025年2月18日 · 解码无功能的核糖体通过空缺的A位点触发GCN2依赖的eIF2α磷酸化，激活胁迫反应（ISR），但不引起核糖体碰撞。 GCN1优先结合这些解码无功能的核糖体，增强GCN2 …
- 某些结果已被删除