
谷氨酸脱氢酶,在关键代谢分支点的复杂酶 - 知乎
寻找新的gdh激活剂 而hhs是通过gdh刺激[增强的胰岛素分泌的极端形式62,89],ii型糖尿病可能通过gdh活性的控制和限制的增强处理。目前,唯一的合成gdh活化剂是bch。
Glutamate dehydrogenase: Potential therapeutic targets for ...
2023年7月5日 · Glutamate dehydrogenase (GDH), as the catalytic enzyme of glutamate, is an important bridge between carbon and nitrogen metabolism. It is involved in many biological processes, including ammonia metabolism, amino acid and carbohydrate metabolism, energy production, insulin secretion, and neurotransmitter recycling (Smith et al., 2019).
Glutamate dehydrogenase (GDH) regulates bioenergetics and …
2016年2月24日 · Whether and how GDH contributes to the development of glioma remains unknown. Here we report that GDH is a mitochondrial regulator for alpha-ketoglutarate (α-KG) in glioma cells. GDH expression and activity are up-regulated in human glioma cell lines and tissues, and high level of GDH predicts poor outcome.
The Glutamate Dehydrogenase Pathway and Its Roles in Cell and …
Glutamate dehydrogenase is a hexameric enzyme that catalyzes the reversible conversion of glutamate to α-ketoglutarate and ammonia while reducing NAD(P) + to NAD(P)H. GDH is found in all living organisms, with lower life forms often expressing distinct GDH isoenzymes with strict specificity for NAD + or NADP +.
Glutamate Dehydrogenase: Structure, Allosteric Regulation, and …
Glutamate dehydrogenase (GDH) is a homohexameric enzyme that catalyzes the reversible oxidative deamination of l -glutamate to 2-oxoglutarate. Only in the animal kingdom is this enzyme heavily allosterically regulated by a wide array of metabolites. The major activators are ADP and leucine and inhibitors include GTP, palmitoyl CoA, and ATP.
A non‐redundant role of EAAT3 for ATP synthesis mediated by GDH …
2025年3月5日 · In both retinoic acid-differentiated SH-SY5Y cells and primary rat mesencephalic neurons challenged with α-synuclein plus rotenone to mimic PD, BCH-dependent GDH activation significantly ameliorated cell viability, improved mitochondrial ATP synthesis and lessened to control levels the cellular redox burden.
Glutamate Dehydrogenase, a Complex Enzyme at a Crucial …
Glutamate dehydrogenase (GDH) is found in all living organisms and catalyzes the oxidative deamination of L-glutamate to α-KG using NAD (P) + as a coenzyme (Fig. 1) [1]. This homohexameric mitochondrial enzyme has subunits comprised of ~ 500 amino acids in animals.
The Glutamate Dehydrogenase Pathway and Its Roles in Cell …
2017年2月8日 · Glutamate dehydrogenase (GDH) is a hexameric enzyme that catalyzes the reversible conversion of glutamate to α-ketoglutarate and ammonia while reducing NAD(P)⁺ to NAD(P)H. It is found in all living organisms serving both catabolic and anabolic reactions.
Glutamate dehydrogenase (GLDH,GDH) - MedChemExpress
Glutamate dehydrogenase (GLDH,GDH) is a hexameric enzyme that catalyzes the conversion of glutamate to α-ketoglutarate and ammonia, while reducing NAD (P)+ to NAD (P)H. GDH pathway is linked to diverse cellular processes, including ammonia metabolism, acid-base equilibrium, redox homeostasis , lipid biosynthesis, and lactate production. [1].
Glutamate Dehydrogenase, a Complex Enzyme at a Crucial
2017年10月27日 · In-vitro, glutamate dehydrogenase (GDH) catalyzes the reversible oxidative deamination of glutamate to α-ketoglutarate (α-KG). GDH is found in all organisms, but in animals is allosterically regulated by a wide array of metabolites. For many years, it was not at all clear why animals required such complex control.