MAP3K1 (or MEKK1) is a serine/threonine kinase and ubiquitin ligase that performs a pivotal role in a network of enzymes integrating cellular receptor responses to a number of mitogenic and metabolic stimuli, including: TNF receptor superfamily (TNFRs), T-cell receptor (TCR), Epidermal growth factor receptor (EGFR), and TGF beta receptor (TGFβR)...

1996年1月23日 · We describe here the cloning and characterization of a cDNA encoding a protein kinase that has high sequence homology to members of the mitogen-activated protein kinase (MAPK) kinase kinase (MAPKKK or MEKK) family; this cDNA is named cATMEKKI (Arabidopsis thaliana MAP kinase or ERK kinase kinase 1). …

2023年11月9日 · Enjoy the Mekk-Knights in this quirky build featuring the new TCG World Premiere Warrior duo! Provided Decklist: Monsters: 21 | Mekk-Knight Avram ||| Mekk-Knight Purple Nightfall | Mekk-Knight Indigo Eclipse | World Legacy – “World Wand” | World Legacy – “World Armor” | Mekk-Knight Red Moon | Mekk-Knight Yellow Star | Mekk-Knight ...

2008年11月4日 · Mitogen-activated protein kinase (MAPK) cascades play important roles in regulating plant innate immune responses. In a genetic screen to search for mutants with constitutive defense responses, we...

2007年5月14日 · Mitogen-activated protein kinases (MAPKs) are members of a dynamic protein kinase network through which diverse stimuli regulate the spatio-temporal activities of complex biological systems.

2018年8月7日 · MAPK/ERK kinase (MEK) 1/2 are central signaling proteins that serve as specificity determinants of the MAPK/ERK cascade. More than twenty activating mutations have been...

2023年10月20日 · After a long time we uploaded a Mekk Knight deck. Ken & Gen fits this archetype really well 🇪🇸 -Unete al canal para acceder a sus beneficios y ayudarnos a ...

1996年6月1日 · Mitogen-activated protein kinases (MAPKs) are a group of serine/threonine specific, proline directed, protein kinases which are activated by a wide spectrum of extracellular stimuli. MAPK activation is achieved through kinase cascades, which include a MAPK kinase (MAPKK or MEK) and a MAPKK/MEK kinase (MAPKKK/MEKK).

2011年2月25日 · Among 19 MAP3Ks in the mammalian genome, MEKK2 and MEKK3 are two highly conserved members of the MEK kinase (MEKK) subgroup of the MAP3K superfamily. Transient expression of either Map3k2 or Map3k3 in vitro leads to their autoactivation and activates all four major MAPKs: ERK1 and ERK2, p38, JNK, and ERK5 ( …

1996年3月8日 · Titration of MEKK 2 and 3 expression in transfection assays indicated that MEKK 2 preferentially activated JNK while MEKK 3 preferentially activated p42/44 MAPK. These findings define a family of MEKK proteins capable of regulating sequential protein kinase pathways involving MAPK members.