2022年7月1日 · Constructing an engineered strain exclusively producing germacradienol is an effective way to solve this problem. Germacradienol synthase plays a key role in the biosynthesis of germacradienol, which can catalyze the cyclization of farnesyl diphosphate (FPP) to form germacradienol in organisms [10], [11], [12].

(1E,4S,5E,7R)-germacra-1 (10),5-dien-11-ol is a germacrane sesquiterpenoid obtained from germacrane by hydroxylation at C (11) together with dehydrogenation across the C (1)-C (10) and C (5)-C (6) bonds. It is a germacrane sesquiterpenoid and a tertiary alcohol.

Germacradienol (1) and the novel glycosylated derivate germacradienyl-11-O-β-d-glucopyranoside (3) were successfully obtained from engineered strains. The cytotoxic activity against nine human cancer cell lines and antimicrobial activities against a panel of bacteria and fungi of germacradienol analogs derived from engineered strains were ...

Geosmin is responsible for the characteristic odor of moist soil. Incubation of recombinant germacradienol synthase, encoded by the SCO6073 (SC9B1.20) gene of the Gram-positive soil bacterium Strep...

2006年8月3日 · We now report the expression and biochemical characterization of the homologous S. avermitilis protein GeoA, and the confirmation that the recombinant enzyme is indeed a germacradienol/geosmin...

Germacradienol 表现出多种生物活性，包括具有 MIC 值范围为 12.5 至 25.0 μg/mL 的广泛抗菌活性和 IC 50 值范围为 21.0 至 83.5 μM 的细胞毒活性。然而，糖基化的germacradienol是无活性的。

Cane, D.E.; Watt, R.M.: Expression and mechanistic analysis of a germacradienol synthase from Streptomyces coelicolor implicated in geosmin biosynthesis. Proc. Natl.

ChemSpider record containing structure, synonyms, properties, vendors and database links for germacradienol, WWPPXYHMZWDIEN-JBVXONOISA-N

2004年3月10日 · Incubations of [1,1-2H2]FPP (1a), (1R)-[1-2H]FPP (1b), and (1S)-[1-2H]FPP (1c) with germacradienol/germacrene D synthase and analysis of the resulting samples of germacradienol (2) and germacrene D (5) by a combination of 1H, 2H, and 13C NMR and mass spectrometry established that it is H-1si of FPP that is lost in the formation of ...

2022年10月3日 · 倍半萜类germacradien-11-ol (germacradienol) 是土臭素生物合成中的重要中间体。细菌中描述了一种双功能萜烯环化酶，用于形成germacradienol并将其降解为土臭素。萜烯环化酶也被认为可用于担子菌中土臭素的形成，但尚未报道用于子囊菌。