GFI1 Gene - GeneCards | GFI1 Protein | GFI1 Antibody
2024年12月25日 · GFI1 (Growth Factor Independent 1 Transcriptional Repressor) is a Protein Coding gene. Diseases associated with GFI1 include Neutropenia, Nonimmune Chronic …
GFI1 - Wikipedia
Gfi1 (growth factor independence 1) is a transcriptional repressor that plays a critical role in hematopoiesis and in protecting hematopoietic cells against stress-induced apoptosis. Recent …
GFI1 growth factor independent 1 transcriptional repressor
Results demonstrate that GFI1 acts as a tumor suppressor gene in colorectal cancer, where deficiency of Gfi1 promotes malignancy in the colon. Gfi1 plays a key role in MM tumor growth, …
From cytopenia to leukemia: the role of Gfi1 and Gfi1b in blood ...
2015年12月10日 · In addition, the Gfi1 locus is frequently found to be a proviral integration site in retrovirus-induced lymphomagenesis, and new, emerging data suggest a role of Gfi1 in human …
The growth factor independence-1 transcription factor: New …
The growth factor independence-1 (Gfi1) transcription factor is required for proper development of neuroendocrine cells, sensory neurons, and blood. Patients with mutations in Gfi1 exhibit …
独立生长因子1作用机制与相关疾病 - 国际免疫学杂志
独立生长因子1 (growth factor independence 1，GFI1)是锌指蛋白家族中重要的转录抑制子，其主要通过与染色质修饰分子结合从而抑制靶基因转录，并与造血细胞发生、免疫细胞分化和恶性 …
GFI1 tethers the NuRD complex to open and transcriptionally …
2021年12月2日 · Growth factor indepdendent 1 (GFI1) is a SNAG-domain, DNA binding transcriptional repressor which controls myeloid differentiation through molecular mechanisms …
生长因子非依赖性 1 转录抑制因子（GFI1）基因 | MCE
该基因编码一种核锌指蛋白，可作为转录抑制因子发挥作用。 这种蛋白质在不同的发育环境中发挥作用，包括造血和肿瘤发生。 它作为复合物的一部分与其他辅助因子一起发挥作用，以控制 …
Gfi1b regulates the level of Wnt/β-catenin signaling in ... - Nature
2019年3月20日 · Here we show that Gfi1b forms complexes with β-catenin, its co-factors Pontin52, CHD8, TLE3 and CtBP1 and regulates Wnt/β-catenin-dependent gene expression. …
GFI1 growth factor independent 1 transcriptional repressor
2024年9月17日 · Hematopoietic transcription factor GFI1 promotes anchorage independence by sustaining ERK activity in cancer cells. Wang H, Lin Z, Nian Z, Zhang W, Liu W, Yan F, Xiao …