In humans, gamma-glutamyl hydrolase is encoded by the GGH gene. [7] [9] [10] This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [10]

γ-谷氨酰水解酶 （英文：Gamma-glutamyl hydrolase）是一种 催化 以下 化学反应 的 酶 [5][6][7][8]： 这种 溶酶体 或分泌的 硫醇 依赖性 肽酶，在 酸性 pH值 下最活跃。 在人类中，γ-谷氨酰水解酶由GGH 基因 编码。 [7][9][10] 该基因通过去除γ联聚谷氨酸和谷氨酸来催化叶酰聚-γ-谷氨酸和抗叶酰聚-γ-谷氨酸的水解。 [10] ^ Human PubMed Reference:. National Center for Biotechnology Information, U.S. National Library of Medicine. ^ Mouse PubMed Reference:.

2024年12月25日 · GGH (Gamma-Glutamyl Hydrolase) is a Protein Coding gene. Diseases associated with GGH include Tropical Sprue and Cutis Laxa, Autosomal Dominant 1. Among its related pathways are Innate Immune System and Fluoropyrimidine activity. Gene Ontology (GO) annotations related to this gene include hydrolase activity and exopeptidase activity.

2013年9月17日 · γ -Glutamyl hydrolase (GGH) regulates intracellular folate and antifolates for optimal nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. The...

2025年1月4日 · Title: High-Level γ-Glutamyl-Hydrolase (GGH) Expression is Linked to Poor Prognosis in ERG Negative Prostate Cancer. These results indicate that elevated expressions of the tumor-related genes FPGS/GGH and VEGF are correlated with malignancy of thymic carcinoma and B3 thymoma tumors.

2022年1月10日 · Gamma-glutamyl hydrolase (GGH) is a key enzyme in folate metabolism pathway. High expression of GGH is associated with severe clinicopathological features and poor prognosis of several cancers. High GGH expression is also related to cell resistance to antifolate drugs such as methotrexate.

2006年12月1日 · Gamma-glutamyl hydrolase (GGH) is a lysosomal enzyme involved in the metabolism of folates and anti-folates. It acts as an endo- and/or exo-peptidase to cleave gamma-polyglutamate chains that are attached to folates and anti-folates after they enter a …

These data show for the first time that cytoplasmic GGH might play a relevant role in the development and progression of invasive breast cancer, warranting further investigations. Our findings suggest that GGH serve as a potential biomarker of unfavorable clinical outcomes over short-term follow-up in breast cancer.

Gamma-glutamyl hydrolase (GGH) is a lysosomal enzyme involved in the metabolism of folates and anti-folates. It acts as an endo- and/or exo-peptidase to cleave gamma-polyglutamate chains that are attached to folates and anti-folates after they enter a mammalian cell.

2025年2月8日 · This gene catalyzes the hydrolysis of folylpoly-gamma-glutamates and antifolylpoly-gamma-glutamates by the removal of gamma-linked polyglutamates and glutamate. [provided by RefSeq, Jul 2008] publications in PubMed explicitly cited by the gene record in OMIM. publications in PubMed limited specific clinical research.