Hepatocyte growth factor (HGF) or scatter factor (SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells and T cells.

2024年12月25日 · HGF (Hepatocyte Growth Factor) is a Protein Coding gene. Diseases associated with HGF include Deafness, Autosomal Recessive 39 and Rare Autosomal Recessive Non-Syndromic Sensorineural Deafness Type Dfnb. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and MIF Mediated Glucocorticoid Regulation.

1999年2月8日 · Hepatocyte growth factor (HGF) is a polypeptide with mitogenic, motogenic, and morphogenic effects on different cell types including hepatocytes. HGF is expressed as two...

2015年4月1日 · Hepatocyte growth factor (HGF) is a pleiotropic cytokine that has been extensively studied over several decades, but was only recently recognized as a key player in mediating protection of many types of inflammatory and autoimmune diseases.

2011年1月4日 · Using a gene knock-out/knock-in approach and sterotaxic injections of HGF or neutralizing antibody into the striatum in mice reveals the critical role of HGF in the development of the nervous systems. 31 HGF functions as an axonal chemoattractant for spinal motor neurons and for the projection of motor neurons to limb muscle. 32 In addition ...

HGF具有肝脏损伤后启动肝再生的功能，还具有显著的促细胞分裂、细胞运动及血管生成作用。 HGF刺激原代无血清培养的肝细胞DNA的合成，对多种组织器官的生长发育有重要的生理调节功能。 1.具有促进血管内皮细胞增生和新生血管形成的作用，一般认为在血管生成过程中，内皮细胞需要表现出一系列特殊、复杂的行为，包括增殖、迁移、细胞间互相黏着、排成直线以及形成开放的腔样结构，HGF刺激新生血管生成，其作用因子活性较之前更为强大。 2.可促进组织细胞的 …

It has been more than 25 years since HGF was discovered as a mitogen of hepatocytes. HGF is produced by stromal cells, and stimulates epithelial cell proliferation, motility, morphogenesis and angiogenesis in various organs via tyrosine ...

Hepatocyte growth factor/scatter factor (HGF/SF) is an important humoral mediator of liver regeneration and related to molecular mechanisms of hepatocarcinogenesis via paracrine system involving its cellular receptor, c-met.

2002年4月15日 · Hepatocyte growth factor (HGF), a heparin-binding factor, is synthesized as a single-chain inactive precursor (pro-HGF), which is converted by proteolysis to an active heterodimer (mature HGF). HGF has pleiotropic activities and has been implicated in the regulation of mitogenesis, motogenesis, and morphogenesis of epithelial and endothelial cells.

Under normal conditions, hepatocyte growth factor (HGF)-induced activation of its cell surface receptor, the Met tyrosine kinase (TK), is tightly regulated by paracrine ligand delivery, ligand activation at the target cell surface, and ligand activated receptor internalization and degradation.