Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in childhood growth, and has anabolic effects in adults. [5] .

2021年9月2日 · 胰岛素样生长因子-1 (Insulin-like growth factor，IGF-1） 是一种在人体内生长激素（GH）刺激下产生的激素，当垂体前叶分泌GH进入血液循环时，几乎数分钟内GH即可以在肝内促进肝脏细胞合成分泌IGF-1。 IGF-1是70个氨基酸的单链多肽，分子量7649，和胰岛素原有50%的序列相同。 生长激素的主要效应是通过IGF-1介导而起作用，IGF-1主要由肝脏细胞合成和分泌，一些局部组织，如神经组织、骨组织、肿瘤细胞等也能产生少量IGF-1，以自分泌、旁分 …

胰岛素样生长因子-1 (IGF-1) 是一种激素，与生长激素一起（GH），有助于促进正常的骨骼和组织生长发育。 IGF-1检测可用于评估生长发育迟缓的青少年儿童。 IGF-1 主要由肝脏、骨骼肌和许多其他组织响应 GH 刺激产生。 IGF-1 介导 GH 的许多作用，刺激骨骼和其他组织的生长，并促进肌肉质量的产生。 IGF-1 还在非生长活动中发挥作用，例如葡萄糖、脂肪代谢，与代谢综合征有关。 由于 GH 全天以 脉冲形式 释放到血液中，因此临床对单次GH 测试的结果很难分析得出结论 …

IGF-1是一种既有胰岛素样合成代谢作用，又有促生长作用的多肽类生长因子，主要由肝脏合成，与其受体结合后启动两条信号传递链：RAS-RAF-MAPK和PI3K-PKB/AKT， 促进 有丝分裂 与细胞生长 [2]。 GH（通过直接结合靶细胞）与IGF-1（通过自分泌与旁分泌）本身可以独立地发挥作用，但它们之间也可以相互影响：一般来说，GH并非直接发挥作用，而是依靠“指使”肝细胞释放IGF-1，后者才是我们发育、长个的真正功臣；IGF-1也可以通过下丘脑作用反过来抑制GH释 …

Secretion of growth hormone (GH), and consequently that of insulin-like growth factor 1 (IGF-1), declines over time until only low levels can be detected in individuals aged ≥60 years. This phenomenon, which is known as the 'somatopause', has led to recombinant human GH being widely promoted and abu …

2023年6月27日 · 胰岛素样生长因子1（Insulin-Like Growth Factor-1，IGF-1）是一种对细胞的增殖分化和人体的生长发育具有关键作用的调控因子。 临床上由生长激素（Growth Hormone，GH）分泌异常导致的肢端肥大症（Acromegaly）、生长激素缺乏型（Growth Hormone Deficiency，GHD）矮小症等疾病的筛查与诊断，以及接受重组人生长激素（Recombinant Human Growth Hormone，rhGH）治疗的患者的用药监测，均需要进行IGF-1 …

2024年4月4日 · The developmental establishment of GH control over the IGF1, IGFBP3 and IGFALS genes in early childhood initiates the dominance of the ternary complex formed by IGF-I or IGF-II and IGFBP-3 (or IGFBP-5) and ALS as the quantitatively most important circulating form of IGF-I and IGF-II (reviewed by Baxter .

2024年11月23日 · Among these, insulin-like growth factor 1 (IGF-1), produced primarily in the liver, mediates many of the growth-promoting effects of GH, acting both locally and systemically to stimulate cell growth and survival [4, 5, 6].

2025年3月11日 · While the liver is the primary site for IGF-1 production, GH also acts on muscle, adipose tissue, and bone, influencing protein synthesis, fat metabolism, and skeletal development. In skeletal muscle, GH enhances protein synthesis and inhibits degradation, promoting hypertrophy and repair through the PI3K-Akt-mTOR pathway. GH-induced IGF-1 ...

4 天之前 · While growth hormone (GH) is hypothesized to potentially enhance embryo quality, results of current basic and clinical researches remain inconclusive. This study assesses the effect of GH supplementation on embryo quality and explores the relationship between baseline insulin-like growth factor-1 (IGF-1) levels and the efficacy of GH supplementation among Chinese patients undergoing in vitro ...