糖皮质激素诱导的亮氨酸拉链蛋白 (glucocorticoid-ind uced leucine zipper,GILZ)是近年来新发现的一个转录因子,属于转录因子TSC-22 (transforming growth factorβ-stimulated clone-22)家族。 本文主要对GILZ的免疫抑制和抗炎功能、促进骨髓源性间充质干细胞 (bone marrow-derived mesenchymal stem cells,BM-MSC)的成骨细胞分化和抑制成脂肪细胞分化功能作一综述。

Glucocorticoid-induced leucine zipper (GILZ) was originally discovered in studies aimed at characterizing genes targeted by dexamethasone. The first suggestion that GILZ plays an important role in GC immunomodulation came from observations of GILZ up-regulation by GCs, mainly in lymphoid organs, and inhibition of anti-CD3-induced activation and ...

2013年5月7日 · 本文主要对 GILZ 的免疫抑制和抗炎功能、促进骨髓源性间充质干细胞(bone marrow-derived mesenchymal stem cells, BM-MSC) 的成骨细胞分化和抑制成脂肪细胞分化功能作一综述。

2021年12月30日 · The role of GILZ as an inhibitor of immune and inflammatory responses mediated by T lymphocytes has been confirmed by studies that have detected GILZ expression in the synovium of humans with rheumatoid arthritis (RA) and of mice with collagen-induced arthritis (CIA), the severity of which is enhanced by GILZ silencing [13,60].

2019年8月6日 · Glucocorticoid-induced leucine zipper (GILZ) is a protein with multiple biological roles that is upregulated by glucocorticoids (GCs) in both immune and non-immune cells. Importantly, GCs are immunosuppressive primarily due to their regulation of cell signaling pathways that are crucial for immune system activity.

2011年5月10日 · GILZ affects several major cell signaling pathways that regulate target genes involved in cell growth, cell differentiation, cell survival and inflammation. GILZ antagonizes cell growth by...

Glucocorticoid-induced leucine zipper (GILZ) is a dexamethasone-inducible gene that mediates glucocorticoid (GC) actions in a variety of cell types, including many cells of immune system. In particular, GILZ can control T cell activities, such as ...

We have identified a gene, glucocorticoid-induced leucine zipper (GILZ or tsc22d3), that is rapidly and invariably induced by GCs. Human GILZ is a 135-amino acid protein that mediates many GC effects, including inhibition of the NF-κB and MAPK pathways.

2021年12月30日 · Here, we examine the mechanisms of GILZ in the context of GC. Specifically, we review its role in the proliferation and differentiation of cells and in apoptosis. We also examine its involvement in immune cells (macrophages, neutrophils, dendritic cells, T and B lymphocytes), and in non-immune cells, including cancer cells.

Amongst a long list of genes activated by GCs is the Glucocorticoid Induced Leucine Zipper (GILZ). GC induced GILZ expression has been well established in lymphocytes and mediates GC induced apoptosis. Unlike lymphocytes, cardiomyocytes respond to GCs by gaining resistance against apoptosis.