2014年8月11日 · Our data reveal that the suppression of Hh signaling in the absence of cellular contacts is independent of primary cilia and is mediated by the YAP oncogene. Overexpression of YAP blocks Hh...

Our findings established a novel signaling mechanism by which the interaction between Gli1 and YAP1 promotes ESCC cell growth. This signaling regulation of the tumorigenesis provides a new therapeutic strategy for highly lethal ESCC. Keywords: Gli1; YAP1; esophageal squamous cell carcinoma; tumorigenesis.

2024年11月6日 · With the development of neuroscience, understanding the functions of YAP in the physiological or pathological processes of glia is advancing. In this review, we aim to summarize the roles and underlying mechanisms of YAP in glia and glia-related neurological diseases in an integrated perspective.

The transcriptional coactivators yes-associated protein (Yap) and transcriptional coactivator with PDZ-binding motif (Taz) function as mechanosensors in cancer cells and have been implicated in the regulation of myofibroblasts in the kidney.

2017年8月5日 · 转录共激活因子是相关蛋白（Yap）和具有PDZ结合基序的转录共激活因子（Taz）在癌细胞中起机械传感器的作用，并参与肾脏中成纤维细胞的调节。 我们假设肾纤维化的发展取决于Yap诱导的肾成纤维细胞的活化和增殖。

Yap/Taz Deletion in Gli-Derived Myofibroblasts Partially Reversed UUO-Induced Kidney Fibrosis. To test whether Yap is a therapeutic target, we studied Yap f/f /Taz f/f /Gli1-ERCre mice after creation of a release-UUO injury. This model can be used to determine if deletion of Yap can reverse UUO-induced kidney fibrosis.

2019年5月1日 · Yes-associated Protein (YAP) is an oncogene in many cancer types, and high YAP expression was correlated with worse overall survival of RCC patients according to The Cancer Genome Atlas (TCGA) database. However, whether YAP promotes tumor angiogenesis of RCC is still unknown.

结论: Yap/Taz信号激活促进了肾脏Gli1+肌成纤维细胞的增殖,活化,参与肾脏纤维化的发生,发展. 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析等技术，为科研工作者提供全面快捷的学术服务。 在这里我们保持学习的态度，不忘初心，砥砺前行。

2024年11月6日 · Yes-associated protein (YAP), the key transcriptional co-factor and downstream effector of the Hippo pathway, has emerged as one of the primary regulators of neural as well as glial cells. It has been detected in various glial cell types, including Schwann cells and olfactory ensheathing cells in th …

2024年11月30日 · In this review, we summarise the evidence on how YAP and TAZ are activated in epidermal keratinocytes; how YAP/TAZ-mediated signalling cooperates with other signalling molecules at the plasma membrane, cytoplasmic, and nuclear levels; and how YAP/TAZ ultimately controls transcription programmes, defining epidermal cell fate.