2024年12月25日 · GLIS2 (GLIS Family Zinc Finger 2) is a Protein Coding gene. Diseases associated with GLIS2 include Nephronophthisis 7 and Acute Megakaryoblastic Leukemia In Children Without Down Syndrome. Among its related pathways is Ciliopathies.

GLIS family zinc finger 2 also known as GLIS2 is a human gene. [1][2] The protein encoded by this gene is a Kruppel-like transcription factor which functions depending on the gene and promoter context as an activator or repressor of gene transcription. [2] . GLIS2 plays a role in kidney development and neurogenesis. [2]

2024年5月1日 · Inactivation of Glis2 suppresses polycystic kidney disease in mouse models of ADPKD, and pharmacological targeting of Glis2 with antisense oligonucleotides slows disease progression. Glis2...

2020年6月1日 · GLIS2 deficiency caused the elevation of H3K27ac and p53 binding on the PUMA enhancer, and promoted PUMA expression. It increased the rate of apoptosis, but not cell cycle. Moreover, GLIS2...

Glis2 is one of three Glis transcription factor family members whose zinc fingers share high homology with the Gli family. Like the Gli proteins, Glis2 is detected in the primary cilium, but it is not required for proper cilia formation.

2025年2月8日 · Study identified Glis2 as a transcription factor mutated in Nephronophthisis and demonstrate its essential role for the maintenance of renal tissue architecture through prevention of apoptosis and fibrosis. Glis2 functions as a negative …

2024年5月1日 · Inactivation of Glis2 suppresses polycystic kidney disease in mouse models of ADPKD, and pharmacological targeting of Glis2 with antisense oligonucleotides slows disease progression. Glis2 transcript and protein is a functional target of CDCA and a potential therapeutic target for treating ADPKD.

In this study, we describe the characterization of a gene encoding a novel Krüppel-like protein, named Glis2. Glis2 encodes a relatively proline-rich, basic 55.8-kDa protein. Its five tandem Cys2-His2 zinc finger motifs exhibit the highest homology to those of members of the Gli and Zic subfamilies of Krüppel-like proteins.

2020年6月1日 · GLIS2 deficiency caused the elevation of H3K27ac and p53 binding on the PUMA enhancer, and promoted PUMA expression. It increased the rate of apoptosis, but not cell cycle. Moreover, GLIS2 represses H3K27ac level on enhancers, regulates the gene expression related with focal adhesion and promotes cell migration, through inhibiting p300.

关于 glis2 Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,314,761-4,339,595 (from NCBI) This gene has 2 transcripts (splice variants), 1 gene allele, 253 orthologues, 14 paralogues and is associated with 4 phenotypes.