Excitatory amino acid transporter (EAAT) 1 and EAAT2 are Na + -dependant glutamate transporters expressed predominantly in glia cells of the central nervous system. As the most abundant glutamate transporters, their primary role is to modulate levels of glutamatergic excitability and prevent spill over of glutamate beyond the synapse.

L-Glutamate (Glu) is the major excitatory neurotransmitter in the mammalian CNS and five types of high-affinity Glu transporters (EAAT1–5) have been identified. The transporters EAAT1 and EAAT2 in glial cells are responsible for the majority of Glu ...

谷氨酸转运体有高亲和力转运体,即兴奋性氨基酸转运体(excitatory amino acid transporters, EAATs)和低亲和力转运体,即囊泡谷氨酸转运体(vesicular glutamate transporters, VGLUTs)两种类型。 其中,VG LUTs的功能是特异地将突触囊泡外的谷氨酸转运进入突触囊泡内,它包括三个成员,分别是VGLUT1、VGLUT2和VGLUT3。 一方面,VGLUT1和VGLUT2标记了所有的谷氨酸能神经元,是谷氨酸能神经元和它们轴突末端高度特异的标志;另一方面,VGLUT1标志着皮质-皮质投射, …

2024年11月26日 · 兴奋性氨基酸转运体（EAATs）家族通过将谷氨酸回收回神经元和星形胶质细胞，迅速从突触间隙和周围细胞外空间中移除谷氨酸，从而帮助终止谷氨酸的兴奋信号。 通过这种方式，EAATs管理： 1、维持谷氨酸信号的时间保真度。 通过从突触间隙中移除谷氨酸，它们防止了初始信号发送后对突触后受体的过度刺激，这会损害对下一个到达信号的检测。 2、维持信号的空间保真度，防止谷氨酸从其释放的突触中“逃逸”，并刺激意外的突触外或突触谷氨酸受体。 3 …

EAAT1 is highly expressed in the neocortex and cerebellum, especially in astrocytes [2,19]; EAAT2 is the main glutamate transporter found in the forebrain; it is abundantly expressed in astrocytes and in a limited extent also on presynaptic nerve terminals [2,20].

L-Glutamate (Glu) is the major excitatory neurotransmitter in the mammalian CNS and five types of high-affinity Glu transporters (EAAT1-5) have been identified. The transporters EAAT1 and EAAT2 in glial cells are responsible for the majority of …

Here we study the differential roles of the EAAT1, EAAT2 and EAAT5 subtypes in glutamate (GLU) uptake at the photoreceptor-to-depolarizing bipolar cell synapse in intact dark-adapted retina. Various doses of EAAT blockers and/or GLU were injected into the eye before the electroretinogram (ERG) was measured.

2017年9月21日 · Excitatory amino acid transporters (EAATs) are responsible for the reuptake of glutamate, preventing non-physiological spillover from the synapse. Postmortem studies...

2015年2月1日 · On the basis of their relative Glu transport rates and anion currents, EAATs group into two functionally distinct classes, EAAT1–3 being efficient Glu transporters with small associated macroscopic anion currents and EAAT4–5 low-capacity transporters with predominant anion conductance [18].

The astrocytic glutamate transporters excitatory amino acid transporters 1 and 2 (EAAT1 and EAAT2) play a key role in nervous system function to maintain extracellular glutamate levels at low levels. In physiology, this is essential for the rapid ...