A-kinase anchor protein 9 is a protein that in humans is encoded by the AKAP9 gene. [3][4][5] AKAP9 is also known as Centrosome- and Golgi-localized protein kinase N-associated protein (CG-NAP) or AKAP350 or AKAP450 [6]

2002年10月25日 · The protein kinase A-anchoring proteins (AKAPs) are defined by their ability to scaffold protein kinase A to specific subcellular compartments. Each of the AKAP family members utilizes unique targeting domains specific for a particular subcellular compartment. AKAP350 is a multiply spliced AKAP fami …

2002年10月25日 · AKAP350 is a multiply spliced AKAP family member localized to the centrosome and the Golgi apparatus. Three splicing events in the carboxyl terminus of AKAP350 generate the AKAP350A, AKAP350B, and AKAP350C proteins.

2024年12月24日 · This gene encodes a member of the AKAP family. Alternate splicing of this gene results in at least two isoforms that localize to the centrosome and the Golgi apparatus, and interact with numerous signaling proteins from multiple signal transduction pathways.

AKAP targeting concentrates PKA at distinct subcellular locations near sources of cAMP, including the plasma membrane at ion channels and receptors, the Golgi apparatus, the mitochondria (outer membrane and intermembrane space), the centrosome, specific regions within active cytoskeletal machinery, vesicles, and others (Figure 2A,B and Table 1).

2009年4月4日 · We report that microtubule (MT) nucleation at the Golgi apparatus requires AKAP450, a centrosomal γ-TuRC-interacting protein that also forms a distinct network associated with the Golgi. Depletion of AKAP450 abolished MT nucleation at the Golgi, whereas depletion of the cis-Golgi protein GM130 led to the disorganisation of AKAP450 network and ...

2025年2月9日 · Data suggest that recruitment of AKAP450 on Golgi membranes through GM130 allows centrosome-associated nucleating activity to extend to the Golgi, to control the assembly of subsets of microtubules. These results provide the first evidence for the microtubule dependent association of AKAP350A and CCAR1 with RNA stress granules.

AKAPs are a diverse group of molecules that function as cell signaling scaffolds. Specifically, AKAPs dynamically organize and juxtapose protein kinase A (PKA) with specific substrates and other signaling machinery at specific cellular locales.

2017年12月15日 · A-kinase anchor protein 350 kDa (AKAP350A, also called AKAP450/CG-NAP/AKAP9) is a large scaffolding protein located at both the centrosome and Golgi apparatus. Previous findings have suggested that AKAP350 is important for microtubule dynamics at both locations, but how this scaffolding protein assembles microtubule nucleation machinery is unclear.

AKAP350 is a multiply spliced AKAP family member localized to the centrosome and the Golgi apparatus. Three splicing events in the carboxyl terminus of AKAP350 generate the AKAP350A, AKAP350B, and AKAP350C proteins.