2024年12月25日 · GPM6A (Glycoprotein M6A) is a Protein Coding gene. Diseases associated with GPM6A include Retinitis Pigmentosa 29 and Schizophrenia. Gene Ontology (GO) annotations related to this gene include calcium channel activity. An important paralog of this gene is GPM6B.

Neuronal membrane glycoprotein M6-a is a protein that in humans is encoded by the GPM6A gene. [5] [6] [7]

Glycoprotein M6A (GPM6A) is a transmembrane protein on the surface of neurons in the central nervous system. This article reviews the vital roles of GPM6A in neuron development and synapse forming, and the relationship between GPM6A and neuropsychiatric disorders.

2021年5月4日 · Neuronal glycoprotein M6a, encoded by the GPM6A gene is emerging as one of these molecules. M6a has been involved in neuron development and synapse formation and plasticity, and was also recently proposed as a gene-target in various neuropsychiatric disorders where it could also be used as a biomarker.

GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca 2+ influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid ...

2024年9月18日 · In this study, we identified Glycoprotein m6a (Gpm6a) as a critical protein for aMaSC activity modulation by using the Gpm6a knockout mouse model. Interestingly, we determined that Gpm6a depletion results in a reduction of Procr protein stability.

The yeast two-hybrid screen and the coimmunoprecipitation analysis identify the HIV-1 Nef interacting human protein glycoprotein M6A (GPM6A) in cells: PubMed

2025年1月4日 · Clinical resource with information about GPM6A, Biological insights from 108 schizophrenia-associated genetic loci., Common genetic variants associated with cognitive performance identified using the proxy-phenotype method., Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci ...

Predicted to enable Calcium Channel activity. Involved in neuron migration and stem cell differentiation. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]

Gene ID: 234267, updated on 8-Feb-2025. Predicted to enable calcium channel activity. Involved in neural retina development and neuron projection morphogenesis. Acts upstream of or within response to bacterium. Located in axonal growth cone. Is expressed in central nervous system; intraembryonic coelom; metanephros; sensory organ; and upper lip.