2024年12月25日 · GPNMB (Glycoprotein Nmb) is a Protein Coding gene. Diseases associated with GPNMB include Amyloidosis, Primary Localized Cutaneous, 3 and Lichen Amyloidosis. Among its related pathways are Signaling by PTK6 and Signal Transduction. Gene Ontology (GO) annotations related to this gene include heparin binding and integrin binding.

GPNMB is a type I transmembrane glycoprotein which shows homology to the pmel17 precursor, a melanocyte-specific protein. GPNMB has been reported to be expressed in various cell types, including: melanocytes, osteoclasts, osteoblasts, dendritic …

GPNMB, an endogenous glycoprotein, has been recently related to inflammation and neuroinflammation. GPNMB is highly expressed in macrophages and microglia, which are cells involved with innate immune response in the periphery and the brain, respectively.

2022年9月1日 · Glycoprotein-NMB (GPNMB) is a transmembrane glycoprotein that is overexpressed in a variety of cancers. It can promote primary tumor growth and metastasis, and GPNMB expression...

Glycoprotein-NMB (GPNMB) is a transmembrane glycoprotein that is overexpressed in a variety of cancers. It can promote primary tumor growth and metastasis, and GPNMB expression correlates with poor prognosis and shorter recurrence-free survival in patients.

Glycoprotein non-metastatic b (GPNMB) has recently been identified as a gene that is over-expressed in numerous cancers, including TNBC, and often correlates with the metastatic phenotype. In breast cancer, GPNMB expression in the tumor epithelium is associated with a reduction in disease-free and overall survival.

2025年3月4日 · GPNMB overexpression is closely related to a weak immune state in L-Lep. As a key part of innate immunity and a major host of leprosy pathogens, macrophage dysfunction is an important reason for M ...

The glycoprotein nonmetastatic melanoma protein B (GPNMB, also known as osteoactivin) is highly expressed in many cell types and regulates the homeostasis in various tissues. In different physiological contexts, it functions as a ...

本研究通过 单细胞RNA测序 （scRNA-seq）、 bulk RNA-seq 和 空间转录组测序 技术研究 胶质细胞母瘤 （GBM）微环境中的网络特征。 此外，还通过体外联合培养系统、流式细胞仪分析和免疫荧光染色对研究结果进行验证。 综合分析显示，高度异质性的GBM肿瘤细胞可以根据分子研究分为MES样、AC样、OPC样和NPC样亚型。 此外，轨迹和调控网络推断PN到MES的细胞状态转变由特定的转录因子（TF）调节。 重要的是，研究者发现来自巨噬细胞的GPNMB通过免疫细胞 …

一种肿瘤相关抗原作为极具吸引力的治疗靶标而备受关注，它就是 糖蛋白非转移性黑色素瘤蛋白 B (GPNMB)。 GPNMB 过表达已在多种实体肿瘤类型中得到证实，这些肿瘤类型与促迁移、促侵袭和促血管生成表型有关，包括三阴性（HER2-、PR-、ER-）转移性乳腺癌 (TNBC)。 与许多其他肿瘤相关抗原一样，GPNMB 由正常细胞表达，并在免疫和中枢神经系统的生理机能中发挥作用。 虽然 GPNMB 在正常细胞中的表达水平较低，但它在肿瘤细胞表面的表达水平却异常高。 这使 …