2024年12月25日 · GPR78 (G Protein-Coupled Receptor 78) is a Protein Coding gene. Diseases associated with GPR78 include Gastric Cancer and Schizophrenia. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity. An important paralog of this gene is GPR26.

Probable G-protein coupled receptor 78 is a protein that in humans is encoded by the GPR78 gene. [ 3 ] [ 4 ] G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G …

2019年2月12日 · Glucose regulatory protein 78 (GRP78), the master regulator of the UPR, plays a role in proliferation, invasion, and metastasis in cancer. Cancer stem cells (CSCs)...

2025年1月4日 · Knockdown of GPR78 in lung cancer cells suppressed cell migration and GPR78 modulated the formation of actin stress fibers in A549 cells, in a RhoA- and Rac1-dependent manner. Title: GPR78 promotes lung cancer cell migration and metastasis by activation of Gαq-Rho GTPase pathway.

2025年2月8日 · Two haplotypes remained significant in both the female bipolar affective disorder individuals and in the full sample of affected female individuals. Results provide preliminary evidence for involvement of GPR78 in susceptibility to BPAD and SCZ.

Introduction Glucose-Regulated Protein 78kD (GRP78) is a chaperone and the main regulator of the ER-stress response which is triggered by a variety of conditions that disturb folding of proteins in the ER. Upon ER Stress, GRP78 activates the unfolded protein response (UPR), which aims to clear unfolded proteins and restore ER homeostasis.

GPR78 is an orphan G-protein coupled receptor (GPCR) that is predominantly expressed in human brain tissues. Currently, the function of GPR78 is unknown. This study revealed that GPR78 was expressed in lung cancer cells and functioned as a novel regulator of lung cancer cell migration and metastasis …

2024年2月26日 · gpr78重组蛋白是一种重要的蛋白质，在生物学中发挥着重要的作用。 它属于G蛋白偶联受体家族，是一种跨膜蛋白，在细胞信号传导中起着至关重要的作用。

GRP78 BiP (HSPA5)靶点介绍及实验小贴士靶点介绍助您了解其蛋白功能，蛋白特性，蛋白定位及异构体和翻译后修饰等特质。 同时列举了实用的WB实验小贴士，助您实验成功。

该基因编码的蛋白属于 G 蛋白偶联受体家族，包含 7 个跨膜结构域，通过异源三聚体 G 蛋白转导细胞外信号。 这是一种孤儿受体，显示出显着水平的组成性活性。 关联分析显示该基因参与双相情感障碍和精神分裂症易感性的初步证据。 已发现该基因的可变剪接转录物变体。 [RefSeq 提供，2011 年 11 月] The protein encoded by this gene belongs to the G protein-coupled receptor family, which contain 7 transmembrane domains and transduce extracellular signals through …