2022年6月16日 · ScRNA sequencing identified GPR87 as a novel marker of basal cells in IPF, enriched in honeycomb cysts. GPR87 overexpression resulted in aberrant airway cell differentiation. https://bit.ly/3i4dXeT Publication types

2024年10月11日 · Results: GPR87 is highly expressed in IPF lungs, and its expression correlates with disease severity. Furthermore, It is highly expressed in basal and aberrant basaloid cells. GPR87-/-mice are protected against bleomycin induced pulmonary fibrosis. GPR87 knockdown is protective against fibrosis development in normal

2024年10月13日 · GPR87 knockdown is protective against fibrosis development in normal PCLS treated with fibrotic cocktail and leads to fibrosis regression in IPF PCLS. In iBC, GPR87 knockdown leads to decreased expression of fibrosis related genes, proteins and microRNAs. GPR87 stimulation with LPA leads to the opposite results.

Using single-cell RNA sequencing of enriched EpCAM + lung cells of the distal IPF lung, we identified G-protein coupled receptor (GPR) 87 as a marker of distal bronchioles and KRT5 + basal-like cells in IPF.

Results: Reanalysis of the LGRC data revealed that GPR87 was significantly increased in IPF tissues (fold change 12.1, FDR adjusted P<0.001) and expression was inversely correlated with forced vital capacity r=-0.56, p<0.01, and diffusion capacity r=-0.61, p<0.01.

2021年2月1日 · Using CHO cells transfected with pcDNA5 vector containing GPR87-G α16 fusion gene, they examined the effects of P2Y and P2Y-related receptor ligands on intracellular Ca 2+ ([Ca 2+] i) movements...

Here, we report G-protein coupled receptor (GPR) 87 as a marker of distal bronchioles and KRT5 + basal-like cells in IPF. We generated single cell transcriptomes from EpCAM + cells isolated from parenchymal lung tissue from three IPF patients and three age-matched healthy donors.

GPR87 knocked out (KO) mice obtained from Cyagen, as well as wild type mice, were injected with intratracheal bleomycin (2 u/Kg) and were sacrificed 21 days later. Results: LPA treatment of iBC increased expression of fibrosis related genes, including GPR87, CDH2, MMP7 (1.3, 1.25, and 1.5 folds, respectively.)

2024年10月10日 · G- protein coupled receptor 87 (GPR87), an alternative lysophosphatidic acid (LPA) receptor previously implicated in cancer, is highly expressed in basal and aberrant basaloid cells in idiopathic pulmonary fibrosis (IPF). We sought to determine whether signaling through GPR87 is important to the development of pulmonary fibrosis. Methods

GPR87 - a G-Coupled Protein Receptor Overexpressed in Human and Murine Pulmonary Fibrosis, Localizes to Aberrant Basaloid Cells in the IPF Lung (abstract). Am J Respir Crit Care Med 2022;205:A2325.