2017年3月14日 · Finally, we demonstrated that GPR87 enhanced pancreatic cancer aggressiveness by activating NF-κB signaling pathway. Conclusions: Taken together, these findings suggest that GPR87 plays a critical oncogenic role in pancreatic cancer progression and highlight its potential as a target for pancreatic cancer therapy.

2018年5月1日 · PAK4 and belinostat affect cell proliferation and growth via IKKβ and IκBα in the NF-κB signaling pathway. In addition, hypoxia, ABCG2, gastrin, Minnelide, GPR87 and BC06 mediate PI3K/AKT activities to regulate invasion and metastasis in pancreatic cancer cells via the NF-κB signaling pathway and its downstream genes.

According to research, the G protein-coupled receptor is involved in the activation of the NF-kB signal, which in turn activates angiogenesis, gemcitabine chemo-resistance, and proliferation in...

To explore whether GPR87 mediates pancreatic cancer progression through NF-κB activation, luciferase reporter analysis was performed. Our results showed that the stimulatory effect of GPR87 on NF-κB activation was significantly inhibited by transfection of an IκBα dominant-negative mutant (IκBα-mut) or treatment with an NF-κB inhibitor.

研究目的: 胰腺癌是一种高度致死性以及在恶性肿瘤中预后极差的疾病,据报道,GPR87在多种肿瘤中高表达,然而,GPR87在胰腺癌中的临床意义以及生物学特点仍有待研究.

研究发现，在胰腺导管腺癌（pancreaticductal adenocarcinoma，PDAC）细胞中 GPR87 高表达，并且 GPR87 的表达与患者临床病理特征相关；GPR87 能够促进细胞增殖、血管新生及吉西他滨依赖的凋亡耐受；另外，GPR87 通过激活 NF-κB 信号通路增强了胰腺癌的侵袭性。

This finding points towards GPR87 being an anti-apoptotic gene that induces cell proliferation [7]. Overexpression of GPR87 promotes migratory and invasive properties in vitro and increased tumour initiation in vivo [6]. GPR87 enhances pancreatic cancer aggressiveness by activating NF-kB signalling pathway [8]. Clinical studies also suggest ...

2018年7月12日 · 内容提示： 分类号 学号 m201475514学校代码 10487 密级硕⼠ 士 学位论⽂ 文gpr87通过激活 nf-κb信号通路 路 促进胰腺癌的进展学位申请⼈ 人 ：霍永宝学科专业： 外科学（普外）指导教师： 王春友 教授刘涛 教授答辩⽇ 日 期： 2017年 年 5⽉ 月万方数据

2017年3月14日 · Finally, we demonstrated that GPR87 enhanced pancreatic cancer aggressiveness by activating NF-κB signaling pathway. Conclusions: Taken together, these findings suggest that GPR87 plays a...

Each bar represents the mean ± SD of three independent experiments from publication: Overexpression of G protein-Coupled receptor GPR87 promotes pancreatic cancer aggressiveness and activates...