2024年12月25日 · GPT2 (Glutamic--Pyruvic Transaminase 2) is a Protein Coding gene. Diseases associated with GPT2 include Neurodevelopmental Disorder With Spastic Paraplegia And Microcephaly and Postnatal Microcephaly-Infantile Hypotonia-Spastic Diplegia-Dysarthria-Intellectual Disability Syndrome.

Glutamic--pyruvic transaminase 2 is a protein that in humans is encoded by the GPT2 gene. [5] This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes …

2025年2月8日 · This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver.

GPT2 catalyzes the reversible addition of an amino group from glutamate to pyruvate, yielding alanine and α-ketoglutarate. The GPT2 gene demonstrates expression in brain postnatally, and the protein localizes to mitochondria. As in humans, Gpt2 -null mice exhibit reduced brain growth.

2024年3月5日 · This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate. Alanine transaminases play roles in gluconeogenesis and amino acid metabolism in many tissues including skeletal muscle, kidney, and liver.

2025年1月4日 · This gene encodes a mitochondrial alanine transaminase, a pyridoxal enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate.

This gene has 5 transcripts (splice variants), 1 paralogue and is associated with 1 phenotype.

The glutamate pyruvate transaminase 2 (GPT2) gene produces a nuclear-encoded mitochondrial enzyme that catalyzes the reversible transfer of an amino group from glutamate to pyruvate, generating alanine and alpha-ketoglutarate. Recessive mutations in GPT2 have been recently identified in a new syndro …

This gene encodes a mitochondrial alanine transaminase, a pyridoxal Enzyme that catalyzes the reversible transamination between alanine and 2-oxoglutarate to generate pyruvate and glutamate.

2019年2月14日 · Here we report that mitochondrial glutamate-pyruvate transaminase 2 (GPT2) contributes to cell survival and growth by sustaining the tricarboxylic acid (TCA) cycle...