Growth factor receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction / cell communication. In humans, the GRB2 protein is encoded by the GRB2 gene. [5][6] The protein encoded by this gene binds receptors such as the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains.

Growth Factor Receptor-bound protein 2 (Grb2) is a key molecule in intracellular signal transduction, linking activated cell surface receptors to downstream targets by binding to specific phosphotyrosine-containing and proline-rich sequence motifs.

2018年2月8日 · In this review, we have compiled the maximum tumor conformations caused by the involvement of the Grb2, the central role of Grb2 in numerous oncogenic pathways and particular approaches that can be useful to downregulate the Grb2 overexpression.

GRB2, or Growth Factor Receptor-Bound Protein 2, is a pivotal adaptor protein in intracellular signal transduction pathways, particularly within receptor tyrosine kinase (RTK) signaling cascades. Its crystal structure reveals a modular architecture ...

5 天之前 · The unbound Grb2-SH2 domain showed fewer and more stable clusters in comparison with Grb2-SH2 domain-drug complexes. Compound DO71_2 showed fewer clusters in comparison with other complexes, which can be correlated with complex stability upon ligand binding. Conversely, Compound DH67_3 has many …

2011年1月1日 · Development of Grb2 Inhibitors as Anticancer Drugs. The recognition that Grb2 is important in several oncogenic signaling pathways is the origin of several efforts to selectively disrupt its intracellular network.

2005年12月1日 · 生长因子受体结合2（Grb2）是一种普遍表达的衔接蛋白，可在细胞表面生长因子受体与Ras信号通路之间提供关键的联系。因此，它与几种重要的人类恶性肿瘤的发生有关。除了此功能外，过去十年的研究还揭示了Grb2在细胞运动性和血管生成中的其他基本作用-这些过程也有助于肿瘤的生长，侵袭性和 ...

1999年10月8日 · CGP78850 is a potent competitor of Grb2 SH2-phosphopeptide interactions. This inhibitor has been obtained by rational drug design and is specific toward the Grb2 SH2 vs. other SH2 domains and the PTB domain of SHC in vitro. Accordingly, CGP78850 blocks epidermal growth factor receptor (EGFR)-Grb2 and Shc-Grb2 interactions in living cells.

Grb2 signaling is critical for cell cycle progression and actin-based cell motility, and, consequently, more complex processes such as epithelial morphogenesis, angiogenesis and vasculogenesis. These functions make Grb2 a therapeutic target for strategies designed to prevent the spread of solid tumors through local invasion and metastasis.

2024年3月31日 · grb2是响应外界生长因子信号后介导ras/mapk信号通路的经典接头蛋白，在细胞质和细胞核中均有表达，但其在细胞核内的功能及其相关机理尚未完全明晰。