Grb2能够同时与Shc、Sos结合形成Shc-Grb2-Sos复合物,并将Sos激活，激活的Sos与质膜上的Ras蛋白结合，并将其激活,引起 信号级联反应。 Grb2蛋白含有一个 SH2结构域 和两个SH3 …

SH2和SH3结构域解释了生长因子受体如何激活Ras并获得信号传递的特异性。Grb2包含两个SH3结构域和一个SH2结构域，它的SH3结构域对Sos中两个不同的富含脯氨酸的序列具有亲 …

GRB2, in turn, binds to the Son of Sevenless (SOS) protein through its SH3 domain. This binding facilitates the activation of Ras, a small GTPase, which triggers a cascade of downstream …

2025年2月20日 · Grb2 mediates FGF-MAPK signaling in lens cell differentiation. If Frs2 is responsible for lens fiber differentiation rather than lens induction, we anticipate that its …

Phosphorylated Shc proteins form a complex with the SH2-SH3 containing Grb2 protein which is implicated in the regulation of Ras, suggesting that Shc is involved in the intracellular …

1998年11月19日 · In this report, we show rapid phosphorylation of Shc upon stimulation of NFS-60 cells with G-CSF, and inducible association of Shc and Grb2 with the G-CSF-R in these …

2012年11月6日 · Grb2 preferentially uses its N-terminal SH3 domain to bind the polyproline sequence in Sos (29–31). Analysis of the crystal structure of the Grb2 dimer shows an …

防止与酪氨酸激酶蛋白或其他衔接子如Shc或IRS1相互作用的Grb2-SH2域抑制剂的设计应提供一种中断Ras信号通路的手段。 新合成的伪肽对Grb2-SH2结构域表现出纳摩尔亲和力。

2021年4月1日 · In non-stimulated cells we find that binding of the adaptor protein Grb2, in its monomeric state, initiates Shp2 activity independent of phosphatase phosphorylation. Grb2 …

One of the mechanisms of TCR-mediated, tyrosine kinase-dependent Ras activation involves the simultaneous interaction of phosphorylated Shc with the TCR zeta chain and with a second …