GRK5 is widely expressed throughout the body, but with notably high expression in the lung, heart and placenta, with widespread expression at lower levels. [13] In humans, a GRK5 sequence …

2024年12月25日 · GRK5 (G Protein-Coupled Receptor Kinase 5) is a Protein Coding gene. Diseases associated with GRK5 include Atrial Fibrillation and Heart Disease. Among its …

2024年1月15日 · G protein-coupled receptor kinase 5 (GRK5) is an important drug development target for heart failure, cardiac hypertrophy, and cancer. We have designed and developed a …

2020年12月14日 · To delineate how GRKs are regulated by calcium, we set out to determine the molecular basis for GRK5 interaction with Ca 2+ /CaM. Through structural, computational, and …

2024年8月23日 · Background: Our prior genome-wide association study of thrombin-induced platelet aggregation identified a G protein-coupled receptor kinase 5 (GRK5) noncoding …

GRK5 is localized in the centrosome and regulates microtubule nucleation and normal cell cycle progression. GRK5 is a transcriptional modifier of a subset of Galphaq-downregulated genes, …

2017年1月1日 · In humans, the Grk5 gene is located on chromosome 10q26.11 (Aken et al. 2016). The gene contains 16 exons and encodes a 590 amino acid–long protein with a …

本研究首次探讨了grk5对血管新生(angiogenesis)的影响.血管新生主要发生在生理性发育及成体创伤愈合,女性月经周期等过程,受到精密的促血管新生因子和抑制因子的平衡调控,一旦失衡则会 …

2022年1月7日 · G protein-coupled receptor kinase 5 (GRK5) is upregulated in failing human myocardium and promotes maladaptive cardiac hypertrophy in animal models. However, the …

2024年2月12日 · Clinical resource with information about GRK5, A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans., Novel genetic …