Apr 8, 2024 · Graft-versus-host disease (GvHD) is a complication of a stem cell or bone marrow transplant in which the recipient's tissues reject donor cells and launch an immune attack. This can lead to a range of mild to severe symptoms, based on which organs are attacked.

移植物 抗宿主病（GVHD）是由于移植后异体 供者 移植物中的 T淋巴细胞，经 受者 发动的一系列“ 细胞因子风暴 ”刺激，大大增强了其对受者抗原的 免疫反应，以受者 靶细胞 为目标发动 细胞毒 攻击，其中皮肤、肝及肠道是主要的靶目标。 急性移植物抗宿主病 发生率为35%～64% [1]， 慢性移植物抗宿主病 发生率为30％～70％ [2]。 移植后异体供者移植物中的 T淋巴细胞，以受者 靶细胞 为目标发动 细胞毒 攻击而致病。

Dec 14, 2023 · Graft-versus-host disease (GVHD) is a major cause of morbidity and mortality following allogeneic haematopoietic cell transplantation (HCT). Occurs when donor T cells respond to host histoincompatible antigens on the host tissues.

Find information on graft-versus-host disease (GVHD), including the types, managing GVHD, your transplant journey, community support, and resources.

Nov 22, 2017 · Acute and chronic graft-versus-host disease (GvHD) is a major cause of morbidity and mortality in patients who undergo allogeneic haematopoietic cell transplantation (HCT) and affects approximately 30–40% of recipients. Its diagnosis is complicated, and staging of the disease varies dependent upon the transplant centre involved.

移植物 抗宿主反应（graft versus host reaction，GVHR）是由移植物中的 特异性 淋巴 细胞识别 宿主抗原而发生的一种反应，这种反应不仅导致移植失败，还可以给 受者 造成严重后果。 GVHR所引起的疾病称为移植物抗宿主病（graft versus host disease， GVHD），往往导致受者 多器官功能衰竭。 常见于接受骨髓移植的病人，另外也可见于有大量 淋巴组织 的 实质性 器官移植 受者，如小肠移植。 受者的皮肤、肠道、眼是主要的受损器官。 若移植物中 同种异型 反应性 …

Memorial Sloan Kettering has doctors and nurses who are experienced in treating the symptoms of acute and chronic GVHD in both adults and children. The symptoms of graft-versus-host disease (GVHD) depend on which part of the body is affected. See what symptoms to watch for.

Jan 3, 2024 · Graft-versus-host disease (GVHD) is a major factor contributing to mortality and morbidity after allogeneic haematopoietic stem-cell transplantation (HSCT). In the last 3 years, there has been regulatory approval of new drugs and considerable change in clinical approaches to prophylaxis and management of GVHD.

Nov 30, 2017 · Signs of typical acute GVHD include a maculopapular rash; hyperbilirubinemia with jaundice due to damage to the small bile ducts, leading to cholestasis; nausea, vomiting, and anorexia; and watery...

Dec 10, 2021 · Graft-versus-host disease (GVHD) is the main cause of morbidity and mortality in allogeneic hematopoietic stem cell transplant survivors. Patients with acute and chronic GVHD often endure substantial symptom burden and quality of life (QOL) and functional impairments.