2024年12月25日 · GZMB (Granzyme B) is a Protein Coding gene. Diseases associated with GZMB include Stevens-Johnson Syndrome and Peripheral T-Cell Lymphoma. Among its related pathways are Signaling by ALK fusions and activated point mutants and Programmed Cell Death.

2025年2月8日 · Title: A robust gene prognostic index composed of GZMB, IRF1, and TP63 can stratify the risk of two metastatic urothelial carcinoma cohorts based on immune checkpoint blockade therapy. Granzyme B Contributes to Choroidal Neovascularization and Age-Related Macular Degeneration Through Proteolysis of Thrombospondin-1.

2021年1月12日 · GzmB mediates loss of hemidesmosomal proteins, type XVII collagen (COL17) and α6 integrin, in an EBA murine model. We next aimed to elucidate the mechanisms underlying GzmB-mediated PD...

GZMs are a family of serine proteases that were originally identified in the cytotoxic granules of cytotoxic T and NK cells. The most-abundant and best-characterized members, GZMA and GZMB, have been found in several immune and, more recently, non-immune cell types.

Human and murine Granzymes play important roles in immune responses, crucial for eliminating aberrant cells. GzmB, a serine protease initially identified in the granules of cytotoxic lymphocytes, aids in eliminating infected or transformed cells via inducing apoptotic cell death (1).

2022年11月9日 · Our study support the involvement of GzmB-expressing CD8+ T cells in the inflammatory response in patients with NMOSD and provide a potential biomarker for disease immunotherapy effectiveness and disability progression.

2022年5月2日 · The chemical design of activity-sensing reporters of granzyme B (GzmB) represents a potentially effective strategy for monitoring the cytotoxic activity of CD8+ T cells in cancer.

Human granzyme B binds Plasmodium falciparum Hsp70-x and mediates antiplasmodial activity in vitro. A robust gene prognostic index composed of GZMB, IRF1, and TP63 can stratify the risk of two metastatic urothelial carcinoma cohorts based on immune checkpoint blockade therapy.

2014年12月18日 · Granzyme B (GzmB) is a protease with a well-characterized intracellular role in targeted destruction of compromised cells by cytotoxic lymphocytes. However, GzmB also cleaves extracellular matrix components, suggesting that it influences the interplay between cytotoxic lymphocytes and their environm …

2024年12月10日 · Clinical resource with information about GZMB, Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo., and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.